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# Table 2 Input data values for base case, one-way sensitivity analysis and probabilistic sensitivity analysis

Range | Distribution | Source | |||
---|---|---|---|---|---|

Parameters | Baseline |
Upper boundary |
Lower boundary | ||

Cost | |||||

Cost of local recurrence hospitalization (first year) | 10,147.18 | 2971.96 | 17,322.39 | Lognormal | [a] |

Cost of local recurrence outpatient (first year) | 3728.43 | 2305.50 | 5151.35 | Lognormal | [a] |

Cost of distant metastasis hospitalization per year | 10,652.42 | 9233.85 | 12,070.99 | Lognormal | [a] |

Cost of distant metastasis outpatient per year | 2984.55 | 2649.14 | 3319.96 | Lognormal | [a] |

Cost of hospitalization for 3 months before death | 3585.82 | 2533.61 | 4638.03 | Lognormal | [a] |

Cost of outpatient for 3 months before death | 874.56 | 713.96 | 1035.15 | Lognormal | [a] |

Cost of MAST+RECON hospitalization (first year) | 10,221.30 | 9192.74 | 11,249.86 | Lognormal | [a] |

Cost of MAST+RECON outpatient (first year) | 6070.98 | 5233.55 | 6908.42 | Lognormal | [a] |

Cost of BCT hospitalization (first year) | 7475.54 | 4659.50 | 10,291.58 | Lognormal | [a] |

Cost of BCT outpatient (first year) | 6905.61 | 6051.87 | 7759.35 | Lognormal | [a] |

Cost of MAST hospitalization (first year) | 6630.24 | 6114.63 | 7145.85 | Lognormal | [a] |

Cost of MAST outpatient (first year) | 4210.88 | 3608.80 | 4812.97 | Lognormal | [a] |

Annual cost of follow-up for MAST+RECON | 1448.12 | 1166.11 | 1730.13 | Lognormal | [a] |

Annual cost of follow-up for BCT | 1198.82 | 961.66 | 1435.99 | Lognormal | [a] |

Annual cost of follow-up for MAST | 770.22 | 770.22 | 1090.77 | Lognormal | [a] |

Transportation cost of MAST+RECON | 253.97 | 203.17 | 304.76 | Lognormal | [22] |

Cost of losing work of MAST+RECON | 1202.54 | 962.03 | 1443.04 | Lognormal | [b] |

Transportation cost of BCT | 219.34 | 175.47 | 263.20 | Lognormal | [22] |

Cost of losing work of BCT | 997.85 | 798.28 | 1197.42 | Lognormal | [b] |

Transportation cost of MAST | 230.88 | 184.70 | 277.06 | Lognormal | [22] |

Cost of losing work of MAST | 1125.78 | 900.62 | 1350.93 | Lognormal | [b] |

Utilities | |||||

Local recurrence (first year) | 0.779 | 0.641 | 0.917 | Beta | [23] |

Distant metastasis | 0.737 | 0.657 | 0.817 | Beta | [23] |

Disease-free for MSAT+RECON (first year) | 0.868 | 0.694 | 1 | Beta | [24, 25] |

Disease-free for MSAT+RECON (subsequent year) | 0.933 | 0.746 | 1 | Beta | [24, 25] |

Disease-free for BCT (first year) | 0.872 | 0.823 | 0.921 | Beta | [23] |

Disease-free for BCT (subsequent year) | 0.923 | 0.903 | 0.943 | Beta | [23] |

Disease-free for MSAT (first year) | 0.785 | 0.729 | 0.842 | Beta | [23] |

Disease-free for MSAT (subsequent year) | 0.900 | 0.883 | 0.918 | Beta | [23] |

Transition probability | |||||

Local recurrence of MAST+RECON | 0.002908 | 0.002326 | 0.003489 | Beta | [c] |

Distant metastasis of MAST+RECON | 0.016702 | 0.013362 | 0.020042 | Beta | [c] |

Distant metastasis after local recurrence of MAST+RECON | 0.000000 | 0.000000 | 0.100000 | Beta | [c] |

Death after distant metastasis of MAST+RECON | 0.103557 | 0.082845 | 0.124268 | Beta | [c] |

Local recurrence of BCT | 0.002679 | 0.002143 | 0.003215 | Beta | [c] |

Distant metastasis of BCT | 0.009889 | 0.007911 | 0.011867 | Beta | [c] |

Distant metastasis after local recurrence of BCT | 0.201328 | 0.161062 | 0.241593 | Beta | [c] |

Death after distant metastasis of BCT | 0.016491 | 0.013193 | 0.019789 | Beta | [c] |

Local recurrence of MAST | 0.004019 | 0.003215 | 0.004823 | Beta | [c] |

Distant metastasis of MAST | 0.011288 | 0.00903 | 0.013545 | Beta | [c] |

Distant metastasis after local recurrence of MAST | 1.000000 | 0.800000 | 1.000000 | Beta | [c] |

Death after distant metastasis of MAST | 0.335161 | 0.268129 | 0.402193 | Beta | [c] |

Discount rate | 3% | 0 | 5% | Constant |