Cost-effectiveness of different surgical treatment approaches for early breast cancer: a retrospective matched cohort study from China

Yang, Qing; Zhong, Xiaorong; Zhang, Wei; Luo, Ting; He, Ping; Zheng, Hong

doi:10.1186/s12885-021-07840-6

Table 2 Input data values for base case, one-way sensitivity analysis and probabilistic sensitivity analysis

From: Cost-effectiveness of different surgical treatment approaches for early breast cancer: a retrospective matched cohort study from China

		Range		Distribution	Source
Parameters	Baseline	Upper boundary	Lower boundary
Cost
Cost of local recurrence hospitalization (first year)	10,147.18	2971.96	17,322.39	Lognormal	[a]
Cost of local recurrence outpatient (first year)	3728.43	2305.50	5151.35	Lognormal	[a]
Cost of distant metastasis hospitalization per year	10,652.42	9233.85	12,070.99	Lognormal	[a]
Cost of distant metastasis outpatient per year	2984.55	2649.14	3319.96	Lognormal	[a]
Cost of hospitalization for 3 months before death	3585.82	2533.61	4638.03	Lognormal	[a]
Cost of outpatient for 3 months before death	874.56	713.96	1035.15	Lognormal	[a]
Cost of MAST+RECON hospitalization (first year)	10,221.30	9192.74	11,249.86	Lognormal	[a]
Cost of MAST+RECON outpatient (first year)	6070.98	5233.55	6908.42	Lognormal	[a]
Cost of BCT hospitalization (first year)	7475.54	4659.50	10,291.58	Lognormal	[a]
Cost of BCT outpatient (first year)	6905.61	6051.87	7759.35	Lognormal	[a]
Cost of MAST hospitalization (first year)	6630.24	6114.63	7145.85	Lognormal	[a]
Cost of MAST outpatient (first year)	4210.88	3608.80	4812.97	Lognormal	[a]
Annual cost of follow-up for MAST+RECON	1448.12	1166.11	1730.13	Lognormal	[a]
Annual cost of follow-up for BCT	1198.82	961.66	1435.99	Lognormal	[a]
Annual cost of follow-up for MAST	770.22	770.22	1090.77	Lognormal	[a]
Transportation cost of MAST+RECON	253.97	203.17	304.76	Lognormal	[22]
Cost of losing work of MAST+RECON	1202.54	962.03	1443.04	Lognormal	[b]
Transportation cost of BCT	219.34	175.47	263.20	Lognormal	[22]
Cost of losing work of BCT	997.85	798.28	1197.42	Lognormal	[b]
Transportation cost of MAST	230.88	184.70	277.06	Lognormal	[22]
Cost of losing work of MAST	1125.78	900.62	1350.93	Lognormal	[b]
Utilities
Local recurrence (first year)	0.779	0.641	0.917	Beta	[23]
Distant metastasis	0.737	0.657	0.817	Beta	[23]
Disease-free for MSAT+RECON (first year)	0.868	0.694	1	Beta	[24, 25]
Disease-free for MSAT+RECON (subsequent year)	0.933	0.746	1	Beta	[24, 25]
Disease-free for BCT (first year)	0.872	0.823	0.921	Beta	[23]
Disease-free for BCT (subsequent year)	0.923	0.903	0.943	Beta	[23]
Disease-free for MSAT (first year)	0.785	0.729	0.842	Beta	[23]
Disease-free for MSAT (subsequent year)	0.900	0.883	0.918	Beta	[23]
Transition probability
Local recurrence of MAST+RECON	0.002908	0.002326	0.003489	Beta	[c]
Distant metastasis of MAST+RECON	0.016702	0.013362	0.020042	Beta	[c]
Distant metastasis after local recurrence of MAST+RECON	0.000000	0.000000	0.100000	Beta	[c]
Death after distant metastasis of MAST+RECON	0.103557	0.082845	0.124268	Beta	[c]
Local recurrence of BCT	0.002679	0.002143	0.003215	Beta	[c]
Distant metastasis of BCT	0.009889	0.007911	0.011867	Beta	[c]
Distant metastasis after local recurrence of BCT	0.201328	0.161062	0.241593	Beta	[c]
Death after distant metastasis of BCT	0.016491	0.013193	0.019789	Beta	[c]
Local recurrence of MAST	0.004019	0.003215	0.004823	Beta	[c]
Distant metastasis of MAST	0.011288	0.00903	0.013545	Beta	[c]
Distant metastasis after local recurrence of MAST	1.000000	0.800000	1.000000	Beta	[c]
Death after distant metastasis of MAST	0.335161	0.268129	0.402193	Beta	[c]
Discount rate	3%	0	5%	Constant

Source:^a inpatient and outpatient records of patients in the electronic medical record system; ^b Calculated based on the announcement issued by the Statistics Bureau of Sichuan Province of China; ^c From cumulative incidence function
Abbreviations: MAST + RECON Mastectomy with reconstruction; BCT Breast-conserving therapy; MAST Mastectomy

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ISSN: 1471-2407

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