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Table 2 Input data values for base case, one-way sensitivity analysis and probabilistic sensitivity analysis

From: Cost-effectiveness of different surgical treatment approaches for early breast cancer: a retrospective matched cohort study from China

   Range Distribution Source
Parameters Baseline Upper
boundary
Lower
boundary
  
Cost
 Cost of local recurrence hospitalization (first year) 10,147.18 2971.96 17,322.39 Lognormal [a]
 Cost of local recurrence outpatient (first year) 3728.43 2305.50 5151.35 Lognormal [a]
 Cost of distant metastasis hospitalization per year 10,652.42 9233.85 12,070.99 Lognormal [a]
 Cost of distant metastasis outpatient per year 2984.55 2649.14 3319.96 Lognormal [a]
 Cost of hospitalization for 3 months before death 3585.82 2533.61 4638.03 Lognormal [a]
 Cost of outpatient for 3 months before death 874.56 713.96 1035.15 Lognormal [a]
 Cost of MAST+RECON hospitalization (first year) 10,221.30 9192.74 11,249.86 Lognormal [a]
 Cost of MAST+RECON outpatient (first year) 6070.98 5233.55 6908.42 Lognormal [a]
 Cost of BCT hospitalization (first year) 7475.54 4659.50 10,291.58 Lognormal [a]
 Cost of BCT outpatient (first year) 6905.61 6051.87 7759.35 Lognormal [a]
 Cost of MAST hospitalization (first year) 6630.24 6114.63 7145.85 Lognormal [a]
 Cost of MAST outpatient (first year) 4210.88 3608.80 4812.97 Lognormal [a]
 Annual cost of follow-up for MAST+RECON 1448.12 1166.11 1730.13 Lognormal [a]
 Annual cost of follow-up for BCT 1198.82 961.66 1435.99 Lognormal [a]
 Annual cost of follow-up for MAST 770.22 770.22 1090.77 Lognormal [a]
 Transportation cost of MAST+RECON 253.97 203.17 304.76 Lognormal [22]
 Cost of losing work of MAST+RECON 1202.54 962.03 1443.04 Lognormal [b]
 Transportation cost of BCT 219.34 175.47 263.20 Lognormal [22]
 Cost of losing work of BCT 997.85 798.28 1197.42 Lognormal [b]
 Transportation cost of MAST 230.88 184.70 277.06 Lognormal [22]
 Cost of losing work of MAST 1125.78 900.62 1350.93 Lognormal [b]
Utilities
 Local recurrence (first year) 0.779 0.641 0.917 Beta [23]
 Distant metastasis 0.737 0.657 0.817 Beta [23]
 Disease-free for MSAT+RECON (first year) 0.868 0.694 1 Beta [24, 25]
 Disease-free for MSAT+RECON (subsequent year) 0.933 0.746 1 Beta [24, 25]
 Disease-free for BCT (first year) 0.872 0.823 0.921 Beta [23]
 Disease-free for BCT (subsequent year) 0.923 0.903 0.943 Beta [23]
 Disease-free for MSAT (first year) 0.785 0.729 0.842 Beta [23]
 Disease-free for MSAT (subsequent year) 0.900 0.883 0.918 Beta [23]
Transition probability
 Local recurrence of MAST+RECON 0.002908 0.002326 0.003489 Beta [c]
 Distant metastasis of MAST+RECON 0.016702 0.013362 0.020042 Beta [c]
 Distant metastasis after local recurrence of MAST+RECON 0.000000 0.000000 0.100000 Beta [c]
 Death after distant metastasis of MAST+RECON 0.103557 0.082845 0.124268 Beta [c]
 Local recurrence of BCT 0.002679 0.002143 0.003215 Beta [c]
 Distant metastasis of BCT 0.009889 0.007911 0.011867 Beta [c]
 Distant metastasis after local recurrence of BCT 0.201328 0.161062 0.241593 Beta [c]
 Death after distant metastasis of BCT 0.016491 0.013193 0.019789 Beta [c]
 Local recurrence of MAST 0.004019 0.003215 0.004823 Beta [c]
 Distant metastasis of MAST 0.011288 0.00903 0.013545 Beta [c]
 Distant metastasis after local recurrence of MAST 1.000000 0.800000 1.000000 Beta [c]
 Death after distant metastasis of MAST 0.335161 0.268129 0.402193 Beta [c]
Discount rate 3% 0 5% Constant  
  1. Source:a inpatient and outpatient records of patients in the electronic medical record system; b Calculated based on the announcement issued by the Statistics Bureau of Sichuan Province of China; c From cumulative incidence function
  2. Abbreviations: MAST + RECON Mastectomy with reconstruction; BCT Breast-conserving therapy; MAST Mastectomy