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Fig. 6 | BMC Cancer

Fig. 6

From: LncRNA MT1JP plays a protective role in intrahepatic cholangiocarcinoma by regulating miR-18a-5p/FBP1 axis

Fig. 6

MT1JP restrained tumorigenesis in nude mice. HCCC-9810 cells stably transfected with MT1JP or control vector were subcutaneously injected into nude mice, and the tumors were isolated after three weeks. A. The subcutaneous tumors. B. The tumor volume. C. HE staining was performed to detect the pathological changes of tumors. (the scale bar represented as 100 μm, the arrows indicated intervals caused by cell death) D. TUNEL assay was used to detect cell apoptosis in tumors. E. Immunohistochemical staining was used to detect the expression of Ki-67. F. Immunohistochemical staining was used to detect the expression of FBP1. (the scale bar in D-F represented as 50 μm, and arrows in D-F indicated positive cells) G and H. Real-time PCR was performed for measurement of MT1JP and miR-18a-5p expression in tumors. (n = 6, *p < 0.05, ***p < 0.001, compared with pcDNA3.1)

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