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Fig. 6 | BMC Cancer

Fig. 6

From: MicroRNA-545 suppresses progression of ovarian cancer through mediating PLK1 expression by a direct binding and an indirect regulation involving KDM4B-mediated demethylation

Fig. 6

KDM4B modifies H3K9me3 demethylation to promote PLK1 expression. a correlation between KDM4B and PLK1 expression in OC tissues (Pearson’s correlation analysis, r = 0.7525, p < 0.0001); b mRNA expression of KDM4B and PLK1 in OC cells after oe-KDM4B administration determined (two-way ANOVA, *p < 0.05); c protein expression of KDM4B, PLK1 and H3M9me3 in OC cells measured by western blot analysis (relative to GAPDH, two-way ANOVA, *p < 0.05); d enrichment of the PLK1 promoter by anti-KDM4B or anti-H3K9me3 relative to anti-IgG determined by a ChIP assay (two-way ANOVA, #p < 0.05, ##p < 0.01, ###p < 0.001). Representative images are provided. Data were collected from three independent experiments and expressed as mean ± SD

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BMC Cancer

ISSN: 1471-2407

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