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Table 4 Highly frequent major MeSH terms from the included publications on osteosarcoma and cure (n = 24,485)

From: A 10-year bibliometric analysis of osteosarcoma and cure from 2010 to 2019

Rank Major MeSH terms/ MeSH subheadings Frequency Proportion of frequency (%) Cumulative percentage (%)
1 Osteosarcoma / drug therapy 984 4.0188 4.0188
2 Bone Neoplasms / drug therapy 824 3.3653 7.3841
3 Osteosarcoma / pathology 709 2.8957 10.2798
4 Bone Neoplasms / pathology 513 2.0952 12.3749
5 Osteosarcoma / genetics 505 2.0625 14.4374
6 Osteosarcoma / metabolism 457 1.8664 16.3039
7 Antineoplastic Agents / pharmacology 360 1.4703 17.7741
8 Bone Neoplasms / genetics 352 1.4376 19.2118
9 Bone Neoplasms / metabolism 306 1.2497 20.4615
10 Apoptosis / drug effects 292 1.1926 21.6541
11 Sarcoma, Ewing / drug therapy 246 1.0047 22.6588
12 Antineoplastic Combined Chemotherapy / therapeutic use 186 0.7596 23.4184
13 Osteosarcoma / veterinary 176 0.7188 24.1372
14 Sarcoma, Ewing / pathology 171 0.6984 24.8356
15 MicroRNAs / genetics 166 0.678 25.5136
16 Antineoplastic Agents / therapeutic use 165 0.6739 26.1875
17 Bone Neoplasms / therapy 150 0.6126 26.8001
18 Osteosarcoma / therapy 149 0.6085 27.4086
19 Gene Expression Regulation, Neoplastic 141 0.5759 27.9845
20 Cell Proliferation / drug effects 137 0.5595 28.544
21 Osteosarcoma / surgery 137 0.5595 29.1035
22 Bone Neoplasms / surgery 135 0.5514 29.6549
23 Osteosarcoma / diagnosis 116 0.4738 30.1287
24 Bone Neoplasms / diagnosis 111 0.4533 30.582
25 Bone Neoplasms / veterinary 105 0.4288 31.0108
26 Lung Neoplasms / secondary 99 0.4043 31.4152
27 Sarcoma, Ewing / genetics 98 0.4002 31.8154
28 Osteosarcoma / diagnostic imaging 98 0.4002 32.2156
29 Signal Transduction / drug effects 97 0.3962 32.6118
30 Bone Neoplasms / diagnostic imaging 87 0.3553 32.9671
31 Sarcoma, Ewing / diagnosis 85 0.3472 33.3143
32 Sarcoma, Ewing / therapy 82 0.3349 33.6492
33 Sarcoma, Ewing / metabolism 78 0.3186 33.9677
34 Drug Resistance, Neoplasm / genetics 77 0.3145 34.2822
35 Osteosarcoma / secondary 73 0.2981 34.5804
36 Antineoplastic Agents, Phytogenic / pharmacology 72 0.2941 34.8744
37 Cisplatin / pharmacology 72 0.2941 35.1685
38 Bone Neoplasms / mortality 71 0.29 35.4584
39 MicroRNAs / metabolism 68 0.2777 35.7362
40 Doxorubicin / pharmacology 62 0.2532 35.9894
41 Osteosarcoma / mortality 62 0.2532 36.2426
42 Drug Resistance, Neoplasm 62 0.2532 36.4958
43 Sarcoma, Ewing / surgery 62 0.2532 36.749
44 Autophagy / drug effects 54 0.2205 36.9696
45 Biomarkers, Tumor / genetics 53 0.2165 37.186
46 Osteosarcoma / enzymology 53 0.2165 37.4025
47 Gene Expression Regulation, Neoplastic / drug effects 50 0.2042 37.6067