Characteristics | Number | OS | LCSS | ||||
---|---|---|---|---|---|---|---|
HR | 95.0%CI | p | HR | 95.0%CI | p | ||
Age | 740 | ||||||
≤ 59 | 180(24.3%) | 1 | – | 1 | – | ||
60–69 | 200(27.0%) | 1.316 | 0.999–1.733 | 0.051 | 1.213 | 0.899–1.637 | 0.207 |
70–79 | 258(34.9%) | 2.034 | 1.584–2.612 | < 0.001 | 1.714 | 1.301–2.257 | < 0.001 |
≥ 80 | 102(13.8%) | 3.015 | 2.239–4.059 | < 0.001 | 2.398 | 1.722–3.339 | < 0.001 |
Race | 740 | ||||||
White | 600(81.1%) | 1 | – | 1 | – | ||
Black | 71(9.6%) | 0.944 | 0.694–1.285 | 0.714 | 1.048 | 0.748–1.467 | 0.787 |
Other | 69(9.3%) | 0.902 | 0.659–1.235 | 0.520 | 1.022 | 0.730–1.431 | 0.900 |
Gender | 740 | ||||||
Female | 440(59.5%) | 1 | – | 1 | – | ||
Male | 300(40.5%) | 1.302 | 1.089–1.556 | 0.004 | 1.259 | 1.031–1.539 | 0.024 |
Grade | 494 | ||||||
Well differentiated | 387(78.3%) | 1 | – | 1 | – | ||
Moderately differentiated | 86(17.4%) | 0.987 | 0.733–1.329 | 0.932 | 0.948 | 0.674–1.333 | 0.758 |
Poorly differentiated/Undifferentiated | 21(4.3%) | 2.127 | 1.315–3.441 | 0.002 | 2.236 | 1.340–3.732 | 0.002 |
Laterality | 731 | ||||||
Only one side | 701(95.9%) | 1 | – | 1 | – | ||
Bilateral | 30(4.1%) | 4.285 | 2.946–6.234 | < 0.001 | 5.082 | 3.482–7.416 | < 0.001 |
SEER-stage | 720 | ||||||
Localized | 353(49.0%) | 1 | – | 1 | – | ||
Regional | 172(23.9%) | 2.086 | 1.656–2.628 | < 0.001 | 2.313 | 1.762–3.038 | < 0.001 |
Distant | 195(27.1%) | 5.142 | 4.133–6.396 | < 0.001 | 6.630 | 5.177–8.491 | < 0.001 |
Tstage_8th | 591 | ||||||
T1 | 209(35.4%) | 1 | – | 1 | – | ||
T2 | 153(25.9%) | 1.706 | 1.266–2.299 | < 0.001 | 1.752 | 1.193–2.573 | 0.004 |
T3 | 92(15.6%) | 2.545 | 1.844–3.512 | < 0.001 | 3.132 | 2.111–4.648 | < 0.001 |
T4 | 137(23.2%) | 4.055 | 3.051–5.389 | < 0.001 | 5.923 | 4.204–8.343 | < 0.001 |
Nstage_8th | 684 | ||||||
N0 | 587(85.8%) | 1 | – | 1 | – | ||
N1 | 33(4.8%) | 2.115 | 1.438–3.110 | < 0.001 | 2.557 | 1.708–3.830 | < 0.001 |
N2/3 | 64(9.4%) | 3.537 | 2.661–4.701 | < 0.001 | 4.080 | 3.023–5.507 | < 0.001 |
Mstage_8th | 722 | ||||||
M0 | 536(74.2%) | 1 | – | 1 | – | ||
M1 | 186(25.8%) | 4.031 | 3.310–4.910 | < 0.001 | 4.749 | 3.836–5.879 | < 0.001 |
Surgery | 740 | ||||||
No | 212(28.6%) | 1 | – | 1 | – | ||
Yes | 528(71.4%) | 0.235 | 0.194–0.285 | < 0.001 | 0.210 | 0.170–0.260 | < 0.001 |
Radiation | 740 | ||||||
No | 716(96.8%) | 1 | – | 1 | – | ||
Yes | 24(3.2%) | 1.880 | 1.213–2.915 | 0.005 | 2.024 | 1.275–3.213 | 0.003 |
Chemotherapy | 740 | ||||||
No/Unknown | 526(71.1%) | 1 | – | 1 | – | ||
Yes | 214(28.9%) | 2.321 | 1.926–2.797 | < 0.001 | 2.829 | 2.308–3.468 | < 0.001 |
Marital_status | 715 | ||||||
Divorced | 58(8.1%) | 1 | – | 1 | – | ||
Married | 451(63.1%) | 0.805 | 0.582–1.113 | 0.189 | 0.761 | 0.533–1.086 | 0.132 |
Separated | 12(1.7%) | 0.816 | 0.366–1.819 | 0.619 | 0.887 | 0.373–2.110 | 0.786 |
Single | 77(10.8%) | 0.816 | 0.539–1.235 | 0.336 | 0.727 | 0.457–1.158 | 0.180 |
Widowed | 117(16.4%) | 1.041 | 0.720–1.505 | 0.831 | 0.969 | 0.644–1.457 | 0.879 |