Fig. 1
From: The mutation of BCOR is highly recurrent and oncogenic in mature T-cell lymphoma
Validation of K607E mutation on BCOR. a Schematic representation of mutation position and functional domains of the BCOR protein. b Representative sequencing traces of wild-type and K607E mutant BCOR. Lysine (AAG) was changed to Glutamic acid (GAG) at the 607th amino acid of BCOR. Left panel shows sequence obtained from the wild-type genomic DNA. Right panel shows sequence obtained from an NK/T-cell lymphoma sample. Arrows and red letters denote the location of the base change. The mutant sequence trace shows heterozygosity. c The genomic DNA of BCOR from lymphoma patients was analyzed by PCR amplification and Sanger sequencing. BBD, BCL6 Binding Domain; AF9BD, AF9 Binding Domain; ANK, Ankyrin Repeats