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Table 5 Univariate and multivariate analyses of DFS significance of serum bilirubin and TBA levels

From: A nomogram based on pretreatment levels of serum bilirubin and total bile acid levels predicts survival in colorectal cancer patients

Variable

Univariate analysis

Multivariate analysis

 

HR

95% CI

P

HR

95% CI

P

Sex

0.928

0.711–1.212

0.583

   

Age

0.995

0.985–1.006

0.379

   

Somking

2.322

1.495–3.607

< 0.001

1.851

1.184–2.894

0.007

Tumor history

0.949

0.605–1.488

0.819

   

Obstruction

0.504

0.375–0.678

< 0.001

0.576

0.423–0.786

< 0.001

Tumor size

0.990

0.928–1.055

0.750

   

Tumor location

 Rectum

 

Reference

  

Reference

 

 Right colon

0.880

0.614–1.263

0.489

1.191

0.871–1.629

0.275

 Left colon

0.672

0.499–0.904

0.009

1.333

0.915–1.942

0.135

Differentiation

 Well

 

Reference

    

 Moderate

1.284

0.862–1.913

0.219

   

 Poor

1.288

0.688–2.413

0.428

   

T stage

     

0.004

 T1

 

Reference

  

Reference

 

 T2

0.128

0.052–0.314

< 0.001

1.603

0.58–4.429

0.363

 T3

0.177

0.105–0.3

< 0.001

2.361

0.94–5.932

0.067

 T4

0.357

0.27–0.471

< 0.001

3.431

1.353–8.704

0.009

N stage

     

0.008

 N0

 

Reference

  

Reference

 

 N1

1.906

1.37–2.651

< 0.001

1.120

0.75–1.673

0.580

 N2

4.020

2.941–5.495

< 0.001

1.696

1.167–2.466

0.006

TNM stage

     

< 0.001

 I

 

Reference

  

Reference

 

 II

2.242

0.87–5.778

0.095

1.180

0.418–3.33

0.754

 III

4.968

2.008–12.295

0.001

1.980

0.713–5.497

0.190

 IV

28.627

11.687–70.12

< 0.001

10.452

3.842–28.433

< 0.001

 Perineural invasion

1.343

0.976–1.846

0.070

   

 Vascular invasion

1.165

0.826–1.643

0.385

   

 Chemotherapy

0.950

0.729–1.237

0.702

   

 TBIL

0.390

0.267–0.57

< 0.001

0.437

0.292–0.655

< 0.001

 DBIL

0.618

0.429–0.891

0.010

0.583

0.391–0.871

0.008

 TBA

0.408

0.308–0.541

< 0.001

0.634

0.465–0.865

0.004

  1. DFS Disease Free Survival, HR Hazard Ratio, CI Confidence Interval, TBIL Total Bilirubin, DBIL Direct Bilirubin, TBA Total Bile Acid