Fig. 1

Schema of mTOR complexes 1 and 2 and their related molecules. AMPK, AMP-activated protein kinase; E6/E7, human papillomavirus E6 and E7; eIF4E, eukaryotic translation initiation factor 4E; ERK, extracellular signal-regulated kinase; FKBP12, 12-kDa FK506-binding protein; GβL, G-protein β-subunit like protein; GRB, growth factor receptor-bound protein; IRS1, insulin receptor substrate 1; MEK, mitogen-activated protein kinase/ERK kinase; mLST8, mammalian lethal with SEC13 protein 8; mTOR, mechanistic target of rapamycin; PDK1, 3-phosphoinositide-dependent protein kinase 1; PI3K, phosphatidylinositol 3-kinase; p, phosphorylation; p, dephosphorylation; PLD, phospholipase D; RAS, rat sarcoma; Rheb, Ras homolog enriched in brain; SIN1, stress-activated map kinase-interacting protein 1; SOS, son of sevenless homolog; S6, substrate ribosomal protein S6; TSC1/2, tuberous sclerosis 1/2; ULK1, unc-51-like kinase 1; 4E-BP1, eukaryotic translation initiation factor 4E binding protein 1