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Table 3 Univariable and multivariable analysis of overall survival

From: Comprehensive analysis of genomic mutation signature and tumor mutation burden for prognosis of intrahepatic cholangiocarcinoma

 

Univariable

Multivariable

 

HR

95% CI

P-value

HR

95% CI

P-value

Age, years

  < 65

      

  ≥ 65

0.869

0.643–1.175

0.362

   

Gender

 Female

      

 Male

0.686

0.787–1.439

0.686

   

TNM Stage

 I

  

0.000

  

0.000

 II

1.470

0.938–2.305

0.093

1.717

1.092–2.698

0.019

 III

1.743

0.987–3.079

0.055

2.078

1.172–3.685

0.012

 IV

2.716

1.799–4.101

0.000

2.963

1.957–4.485

0.000

TMB, mut/Mb

 Low

      

 High

1.967

1.454–2.660

0.000

1.500

1.085–2.073

0.014

MRS

 Low

      

 High

2.771

2.035–3.773

0.000

2.448

1.758–3.409

0.000

  1. Abbreviations: CI confidence interval; HR hazard ratio
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