Fig. 3
From: SMAD4 haploinsufficiency in small intestinal neuroendocrine tumors
Smad4+/− mice did not develop neuroendocrine tumors or display increased endocrine cell proliferation. a One of two low-grade serrated adenomas found in Smad4+/− mice stained with hematoxylin & eosin, anti-chromogranin A (CgA), anti-serotonin (5-HT), and anti-SMAD4. There was no observable difference between number of CgA-positive endocrine cells in small intestinal crypts (b) or crypt bases (up to and including position + 4) (c)