TY - JOUR AU - Mohammadzadeh, Zahra AU - Omidkhoda, Azadeh AU - Chahardouli, Bahram AU - Hoseinzadeh, Ghazaleh AU - Moghaddam, Kamran Ali AU - Mousavi, Seyed Asadollah AU - Rostami, Shahrbano PY - 2021 DA - 2021/01/09 TI - The impact of ICAM-1, CCL2 and TGM2 gene polymorphisms on differentiation syndrome in acute promyelocytic leukemia JO - BMC Cancer SP - 46 VL - 21 IS - 1 AB - Although arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) are well-tolerated and effective treatments for Acute Promyelocytic Leukemia (APL), Differentiation Syndrome (DS) is a lethal side effect in some patients. The pathogenesis of DS is complex and not well understood; however, it is considered as an inflammatory response due to cytokines release of differentiated cells. Moreover, adhesion molecules that are widely expressed on the surface of differentiated cells and gene expression changes of transglutaminase2 (TGM2) are mechanisms involved in the development of DS. The purpose of this study was to assess the association of single nucleotide polymorphisms (SNP) of Intercellular Adhesion Molecule-1 (ICAM-1), chemokine (C-C motif) ligand 2 (CCL2) and TGM2 as inflammatory factors with differentiation syndrome susceptibility. SN - 1471-2407 UR - https://doi.org/10.1186/s12885-021-07783-y DO - 10.1186/s12885-021-07783-y ID - Mohammadzadeh2021 ER -