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Fig. 6 | BMC Cancer

Fig. 6

From: Ubiquitin-specific protease-44 inhibits the proliferation and migration of cells via inhibition of JNK pathway in clear cell renal cell carcinoma

Fig. 6

USP44 knockdown promotes the proliferation and migration of Caki-1 cells through JNK activity. a Western blotting showed the p-JNK level of Caki-1 cells in short hairpin control (shctrl) and shUSP44#1, and shUSP44#2 groups with or without a JNK inhibitor. (cropping of blots). b BrdU experiment showing the relative proliferation index of Caki-1 cells in shctrl and shUSP44#1, and shUSP44#2 groups with or without a JNK inhibitor. c Image of the Transwell™ result for Caki-1 cells in the shctrl and shUSP44#1, and shUSP44#2 groups with or without a JNK inhibitor, and the histogram shows the number of migrated cells. *p < 0.05 vs. the shctrl DMSO group; **p < 0.01 vs. the shctrl DMSO group; $p < 0.05 vs. the sh#1 DMSO group; $$p < 0.01 vs. the sh#1 DMSO group; ##p < 0.01 vs. the sh#2 DMSO group

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