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Fig. 4 | BMC Cancer

Fig. 4

From: Ubiquitin-specific protease-44 inhibits the proliferation and migration of cells via inhibition of JNK pathway in clear cell renal cell carcinoma

Fig. 4

USP44 knockdown promotes the proliferation and migration of Caki-1 cells. a mRNA expression of USP44 in short hairpin control (shctrl) and shUSP44 groups of Caki-1 cells. b Relative proliferation of shctrl and shUSP44 groups of Caki-1 cells in the CCK8 assay. c Absorbance at 370 nm in shctrl and shUSP44 groups of Caki-1 cells in the BrdU experiment. d, e Expression of mRNA and protein of P21 and cyclin D1 in shctrl and shUSP44 groups of Caki-1 cells. (cropping of blots). f Image of the Transwell™ result in shctrl and shUSP44 groups of Caki-1 cells, and the histogram shows the number of migrated cells. g, h Expression of mRNA and protein of MMP9 and MMP2 mRNA expression in shctrl and shUSP44 groups of Caki-1 cells. (cropping of blots). **P < 0.01 vs. the ctrl group. Data are the mean ± SD

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