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Table 2 Prognostic factors for overall and cancer-specific survival

From: Population-based SEER analysis of survival in colorectal cancer patients with or without resection of lung and liver metastases

 overall survival using Cox regressioncancer-specific survival using Cox regression
unadjustedafull modelbunadjustedafull modelb
HR (95% CI)pcHR (95% CI)pcHR (95% CI)pcHR (95% CI)pc
ResectionNoReference< 0.001Reference< 0.001Reference< 0.001Reference< 0.001
Yes0.62 (0.58–0.65) 0.75 (0.70–0.80) 0.62 (0.58–0.66) 0.75 (0.70–0.80) 
MetastasisLiver onlyReference< 0.001Reference< 0.001Reference< 0.001Reference< 0.001
Lung only0.78 (0.70–0.86) 0.69 (0.62–0.76) 0.75 (0.68–0.84) 0.67 (0.60–0.75) 
Liver and Lung1.62 (1.51–1.74) 1.58 (1.47–1.69) 1.64 (1.52–1.76) 1.59 (1.48–1.71) 
Tumor localizationRightReference< 0.001Reference< 0.001Reference< 0.001Reference< 0.001
Transverse0.91 (0.84–0.98) 1.01 (0.93–1.09) 0.91 (0.84–0.98) 1.01 (0.93–1.10) 
Left0.61 (0.57–0.65) 0.77 (0.72–0.82) 0.61 (0.57–0.65) 0.77 (0.72–0.82) 
Rectosigmoid0.58 (0.53–0.64) 0.72 (0.66–0.80) 0.58 (0.53–0.64) 0.73 (0.66–0.80) 
Rectum0.46 (0.42–0.50) 0.75 (0.68–0.83) 0.46 (0.41–0.50) 0.75 (0.68–0.83) 
T-StageT1 to T3Reference< 0.001Reference< 0.001Reference< 0.001Reference< 0.001
T41.60 (1.52–1.69) 1.44 (1.37–1.52) 1.74 (1.62–1.87) 1.47 (1.40–1.56) 
N-StageN0Reference< 0.001Reference< 0.001Reference< 0.001Reference< 0.001
N11.64 (1.54–1.76) 1.57 (1.47–1.69) 1.74 (1.62–1.87) 1.65 (1.53–1.78) 
GradeG1/2Reference< 0.001Reference< 0.001Reference< 0.001Reference< 0.001
G3/41.73 (1.63–1.82) 1.50 (1.42–1.59) 1.77 (1.67–1.87) 1.53 (1.44–1.62) 
Chemo- and/orNoReference< 0.001Reference< 0.001Reference< 0.001Reference< 0.001
RadiotherapyYes0.29 (0.27–0.30) 0.34 (0.32–0.36) 0.30 (0.28–0.31) 0.35 (0.33–0.37) 
Year of diagnosis2010–2012Reference< 0.001Reference0.044Reference< 0.001Reference0.052
2013–20150.89 (0.84–0.94) 0.94 (0.89–1.00) 0.89 (0.84–0.94) 0.94 (0.89–1.00) 
Age (years)< 50Reference< 0.001Reference< 0.001Reference< 0.001Reference< 0.001
50–641.24 (1.14–1.34) 1.12 (1.03–1.21) 1.21 (1.12–1.31) 1.10 (1.01–1.19) 
65–791.71 (1.58–1.85) 1.35 (1.25–1.47) 1.62 (1.50–1.76) 1.29 (1.19–1.41) 
80+3.59 (3.28–3.94) 1.96 (1.77–2.17) 3.35 (3.05–3.69) 1.85 (1.67–2.05) 
GendermaleReference0.106Reference0.048Reference0.034Reference0.2227
female1.04 (0.99–1.10) 0.95 (0.90–1.00) 1.06 (1.00–1.12) 0.97 (0.92–1.02) 
EthnicityCaucasianReference< 0.001Reference< 0.001Reference< 0.001Reference0.001
African-American1.15 (1.08–1.24) 1.11 (1.04–1.20) 1.15 (1.08–1.24) 1.11 (1.03–1.20) 
other/unknown0.91 (0.83–1.00) 0.91 (0.83–0.99) 0.90 (0.82–0.99) 0.89 (0.81–0.98) 
Marital statusmarriedReference< 0.001Reference< 0.001Reference< 0.001Reference< 0.001
single1.46 (1.38–1.55) 1.21 (1.14–1.28) 1.45 (1.36–1.53) 1.20 (1.13–1.28) 
other/unknown1.12 (1.05–1.21) 1.05 (0.98–1.13) 1.09 (1.01–1.17) 1.02 (0.94–1.10) 
  1. Hazard ratios (HR) with 95% confidence intervals (CI) of Wald type
  2. aunivariate Cox regression analysis; bmultivariable Cox regression analysis; clikelihood ratio test