Genetic mutational analysis of pediatric acute lymphoblastic leukemia from a single center in China using exon sequencing

Table 1 Genetic subtypes and number of pathogenetic mutations in ALL patients (n = 140)

Subtype^a	No. of patients	No. of mutations Per patients	Patients with Ras mutations^b	Patients with Notch mutations^c
ETV6-RUNX1	31	2.1 (0~20)	3 (9.7%)	0 (0%)
HeH	30	1.6 (0~5)	15 (50.0%)	0 (0%)
BCR-ABL1	9	0.8 (0~2)	1 (11.1%)	0 (0%)
EVI1	6	0.7 (0~1)	1 (16.7%)	0 (0%)
SIL-TAL1	5	2.8 (0~5)	0 (0%)	2 (40%)
MLLr	4	1.8 (0~5)	0 (0%)	1 (25%)
TCF3-PBX1	3	0	0 (0%)	0 (0%)
iAMP21	2	11.5 (1~21)	1 (50.0%)	0 (0%)
Hypodiploidy	2	1.0 (0~2)	0 (0%)	0 (0%)

^aHeH High-hyperdiploid (51~67 chromosomes), iAMP21 Intrachromosomal amplification of chromosome 21
^b Number of significant mutations in the genes KRAS, NRAS, FLT3, NF1 and PTPN11
^c Number of significant mutations in the genes NOTCH1 and FBXW7

ISSN: 1471-2407