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Table 1 Genetic subtypes and number of pathogenetic mutations in ALL patients (n = 140)

From: Genetic mutational analysis of pediatric acute lymphoblastic leukemia from a single center in China using exon sequencing

SubtypeaNo. of patientsNo. of mutations Per patientsPatients with Ras mutationsbPatients with Notch mutationsc
ETV6-RUNX1312.1 (0~20)3 (9.7%)0 (0%)
HeH301.6 (0~5)15 (50.0%)0 (0%)
BCR-ABL190.8 (0~2)1 (11.1%)0 (0%)
EVI160.7 (0~1)1 (16.7%)0 (0%)
SIL-TAL152.8 (0~5)0 (0%)2 (40%)
MLLr41.8 (0~5)0 (0%)1 (25%)
TCF3-PBX1300 (0%)0 (0%)
iAMP21211.5 (1~21)1 (50.0%)0 (0%)
Hypodiploidy21.0 (0~2)0 (0%)0 (0%)
  1. aHeH High-hyperdiploid (51~67 chromosomes), iAMP21 Intrachromosomal amplification of chromosome 21
  2. b Number of significant mutations in the genes KRAS, NRAS, FLT3, NF1 and PTPN11
  3. c Number of significant mutations in the genes NOTCH1 and FBXW7