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Table 1 Genetic subtypes and number of pathogenetic mutations in ALL patients (n = 140)

From: Genetic mutational analysis of pediatric acute lymphoblastic leukemia from a single center in China using exon sequencing

Subtypea No. of patients No. of mutations Per patients Patients with Ras mutationsb Patients with Notch mutationsc
ETV6-RUNX1 31 2.1 (0~20) 3 (9.7%) 0 (0%)
HeH 30 1.6 (0~5) 15 (50.0%) 0 (0%)
BCR-ABL1 9 0.8 (0~2) 1 (11.1%) 0 (0%)
EVI1 6 0.7 (0~1) 1 (16.7%) 0 (0%)
SIL-TAL1 5 2.8 (0~5) 0 (0%) 2 (40%)
MLLr 4 1.8 (0~5) 0 (0%) 1 (25%)
TCF3-PBX1 3 0 0 (0%) 0 (0%)
iAMP21 2 11.5 (1~21) 1 (50.0%) 0 (0%)
Hypodiploidy 2 1.0 (0~2) 0 (0%) 0 (0%)
  1. aHeH High-hyperdiploid (51~67 chromosomes), iAMP21 Intrachromosomal amplification of chromosome 21
  2. b Number of significant mutations in the genes KRAS, NRAS, FLT3, NF1 and PTPN11
  3. c Number of significant mutations in the genes NOTCH1 and FBXW7