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Table 4 Multivariable regression analyses on predictors of CINV in the very late period (days 6 to 21) in patients with a CR during the overall observation period

From: Netupitant/palonosetron (NEPA) and dexamethasone for prevention of emesis in breast cancer patients receiving adjuvant anthracycline plus cyclophosphamide: a multi-cycle, phase II study

 

Odds Ratioa

95% CI

P-value

Cycle 1 (n = 98)

 Motion sickness

1.50

0.21; 10.9

0.687

 Pregnancy-related morning sickness

0.40

0.05; 3.00

0.376

 Alcohol intake (every day vs. none)

Not estimable

Not estimable

Not estimable

 Age (≥50 vs. < 50 years)

0.69

0.10; 4.90

0.707

 Nausea over last 24 h (0–10 NRS)

0.74

0.53; 1.03

0.077

 Anxiety over last 24 h (0–10 NRS)

0.88

0.66; 1.17

0.390

Cycle 2 (n = 98)

 Motion sickness

1.50

0.25; 9.07

0.660

 Pregnancy-related morning sickness

0.51

0.10; 2.70

0.429

 Alcohol intake (every day vs. none)

1.05

0.10; 11.6

0.968

 Age (≥50 vs. < 50 years)

0.30

0.05; 1.86

0.197

 Pre-chemotherapy nausea (0–10 NRS)

0.97

0.64; 1.47

0.870

 Pre-chemotherapy anxiety (0–10 NRS)

0.92

0.65; 1.29

0.608

Cycle 3 (n = 100)

 Motion sickness

0.44

0.10; 1.97

0.281

 Pregnancy-related morning sickness

0.67

0.16; 2.87

0.589

 Alcohol intake (every day vs. none)

Not estimable

Not estimable

Not estimable

 Age (≥50 vs. < 50 years)

2.16

0.47; 9.94

0.323

 Pre-chemotherapy nausea (0–10 NRS)

0.65

0.50; 0.85

0.001

 Pre-chemotherapy anxiety (0–10 NRS)

0.88

0.68; 1.15

0.354

Cycle 4 (n = 96)

 Motion sickness

0.11

0.01; 1.03

0.053

 Pregnancy-related morning sickness

1.21

0.14; 10.6

0.862

 Alcohol intake (every day vs. none)

0.77

0.04; 16.3

0.868

 Age (≥50 vs. < 50 years)

0.11

0.01; 1.10

0.061

 Pre-chemotherapy nausea (0–10 NRS)

0.50

0.34; 0.74

0.0006

 Pre-chemotherapy anxiety (0–10 NRS)

1.16

0.78; 1.73

0.470

  1. All patients received NEPA (netupitant/palonosetron) and dexamethasone on day 1 of each cycle; CINV chemotherapy-induced nausea and vomiting, CR complete response (no emesis and no use of rescue medication). CI confidence interval, NRS numeric rating scale (a score of 1 or greater indicating the occurrence of symptoms)
  2. aOdds ratio lower than 1 indicates an increased likelihood of developing CINV events during the very late period