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Table 4 Univariate and multivariate Cox regression analysis of the risk factor for poor overall survival

From: Significance of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio and prognostic nutritional index for predicting clinical outcomes in T1–2 rectal cancer

Parameters

Univariate analysis

Multivariate analysis

HR

95% CI

P value

HR

95% CI

P value

Age > 60 years vs. ≤60 years

1.510

0.481–4.744

0.480

   

Gender Male vs. Female

2.918

0.823–10.341

0.097

   

Smoking No vs. Yes

0.420

0.095–1.863

0.254

   

Alcoholism No vs. Yes

0.734

0.207–2.600

0.631

   

Hypertension Yes vs. No

2.198

0.797–6.063

0.128

   

Diabetes Mellitus Yes vs. No

2.159

0.687–6.780

0.187

   

Coronary Artery Disease Yes vs. No

2.550

0.812–8.010

0.109

   

CEA level ≥ 5 μg/ml vs. < 5 μg/ml

2.380

0.813–6.966

0.113

   

CA19–9 < 37 U/ml vs. ≥37 U/ml

0.046

< 0.001–1702.151

0.567

   

HGB ≥110 g/L vs. < 110 g/L

0.172

0.055–0.542

0.003

0.204

0.057–0.731

0.015

NLR ≥2.80 vs. < 2.80

5.396

1.954–14.896

0.001

3.149

0.933–12.525

0.063

PLR ≥140.05 vs. < 140.05

5.043

1.423–17.874

0.012

1.266

0.277–5.783

0.761

LMR ≥3.88 vs. < 3.88

0.208

0.066–0.652

0.007

0.767

0.202–2.910

0.696

PNI ≥47.1 vs. < 47.1

0.152

0.054–0.427

0.295

0.462

0.127–1.686

0.242

Occult blood No vs. Yes

0.560

0.178–1.759

0.321

   

Distance from anal verge ≤50 mm vs. > 50 mm

2.287

0.645–8.104

0.200

   

Operation procedure Radical resection vs. TEM

1.823

0.514–6.461

0.352

   

Time of operation ≥3 h vs. < 3 h

1.600

0.510–5.026

0.421

   

Blood transfusion perioperation Yes vs. No

3.265

0.429–24.840

0.253

   

Differentiation Poor/Undifferentiate vs. Well/Moderate

1.293

0.729–2.291

0.379

   

Tumor size ≥3 cm vs. < 3 cm

1.409

0.511–3.886

0.508

   

T stage T2 vs. T1

1.999

0.636–6.278

0.236

   

N stage (N1/2 vs. N0)

11.888

4.215–33.532

< 0.001

9.944

3.001–32.954

< 0.001

TNM stage III vs. I

11.888

4.215–33.532

< 0.001

9.944

3.001–32.954

< 0.001

  1. CI confidence interval; HR hazard ratio; CEA carcinoembryonic antigen; CA19–9 carbohydrate antigen 19–9; HGB hemoglobin; NLR neutrophil-to-lymphocyte ratio; PLR platelet-to-lymphocyte ratio; LMR lymphocyte-to-monocyte ratio; PNI prognostic nutritional index; TEM transanal endoscopic microsurgery; TNM tumor-lymph node-metastasis
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