High tumor budding is a strong predictor of poor prognosis in the resected perihilar cholangiocarcinoma patients regardless of neoadjuvant therapy, showing survival similar to those without resection

Table 1 Patient overview in all 78 patients

Factors	All patients (n = 78)
Age (y.o.)	69 (39–87)
Gender (Male / Female)	47 / 31
Neoadjuvant therapy	36
Chemotherapy	25
Chemoradiotherapy	11
PTPE	18
Type of liver resection^a
No liver resection (PD, Extra bile duct resection)	5
S1,5,6,7,8	27
S1,4,5,6,7,8	7
S1,2,3,4	26
S1,2,3,4,5,8	5
Others	8
Histological type: G1 / G2 / G3 / others	49 / 18 / 9 / 2
TNM (UICC 8th)
pT: T0 / T1 / T2 / T3 / T4	1 / 8 / 33 / 12 / 24
pN: N0 / N1 or N2	40 / 38
M1 (Intrahepatic / Extrahepatic)	6 (3 / 3)
Residual tumor status: R0 / R1 / R2	53 / 14 / 11
Postoperative hospital stay (median: days)	45.5 (13–325)
Complication ≥ C-D grade III	32
Postoperative chemotherapy	56

PTPE percutaneous transhepatic portal vein embolization, PD pancreaticoduodenectomy, C-D Clavien-Dindo
^aExpressed as Couinaud’s hepatic segments resected

ISSN: 1471-2407