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Fig. 3 | BMC Cancer

Fig. 3

From: Alteration in the sensitivity to crizotinib by Na+/H+ exchanger regulatory factor 1 is dependent to its subcellular localization in ALK-positive lung cancers

Fig. 3

Effects of NHERF1 knockdown on the sensitivity of H3122 cells to crizotinib. a Rate of cell apoptosis by flow cytometry with 10 μM crizotinib treatments. b Quantification and statistics from (a) and repeated experiments (n = 3). c The knockdown of NHERF1 at protein levels as determined by western blotting (Full-length blots/gels are presented in Suppl Figure 3). d The cell survival from MTS assays in H3122 and NHERF1 knockdown cells in the presence of crizotinib (0, 2, 5, 10, 20 and 50 μM). **p < 0.01, ***p < 0.001

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