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Fig. 4 | BMC Cancer

Fig. 4

From: Elastin is a key factor of tumor development in colorectal cancer

Fig. 4

ELN increases human colon cancer epithelial cell proliferation and invasion. Human colon cancer epithelial cells (Caco-2) were seeded onto plates coated with recombinant ELN protein and cultured in medium with (or without) ELN peptide. Control plates were coated with PBS only. a Cell proliferation was assessed after 6, 12, 24 and 48 h incubation by MTT assay. b A straight scratch was performed in each well and cancer cells invasion and migration were assessed by wound healing. c Wound area was assessed by measuring the wound closure size after 6 and 12 h post scratch, scale bar is 200 μm. n = 4. Results are mean ± SEM. *P < 0.05, ***P < 0.001 compared to cells cultured in normal medium on control plates. ††† < 0.001, compared to cells cultured in medium contain ELN peptide on control plates. #P < 0.05 compared to cells cultured in normal medium on ELN coated plates

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