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Table 4 Mutation types across age of onset groups

From: Mutational landscape differences between young-onset and older-onset breast cancer patients

Mutation TypesYoungOlderOldestTOTALp-value (young vs. older)p-value (young vs. oldest)
C > A7322 (17%)103,484 (16%)63,664 (17%)110,806 (16%)0.015*0.01*
C > G7012 (17%)109,206 (17%)60,090 (16%)116,218 (17%)0.590.11
C > T13,500 (32%)240,760 (38%)149,492 (40%)254,260 (38%)0.009*0.003*
T > A4374 (10%)50,176 (8%)26,578 (7%)54,550 (8%)0.500.70
T > C5764 (14%)80,644 (13%)47,058 (13%)86,408 (13%)0.680.41
T > G3898 (9%)50,366 (8%)29,430 (8%)54,264 (8%)0.560.67
  1. Frequency and proportion of mutation types among young-onset (diagnosed at ≤40 years of age, n = 89), older-onset (diagnosed at > 40 years of age, n = 949), and oldest-onset (diagnosed at > 60 years of age, n = 465) breast tumours. Entries are number of mutations (% of SNVs in age group). The p-values were calculated using a Welch Two Sample t-test (* indicates statistical significance at the 0.05 level). SNV: Single Nucleotide Variant