Mutational landscape differences between young-onset and older-onset breast cancer patients

BMC Cancer

Table 4 Mutation types across age of onset groups

Mutation Types	Young	Older	Oldest	TOTAL	p-value (young vs. older)	p-value (young vs. oldest)
C > A	7322 (17%)	103,484 (16%)	63,664 (17%)	110,806 (16%)	0.015*	0.01*
C > G	7012 (17%)	109,206 (17%)	60,090 (16%)	116,218 (17%)	0.59	0.11
C > T	13,500 (32%)	240,760 (38%)	149,492 (40%)	254,260 (38%)	0.009*	0.003*
T > A	4374 (10%)	50,176 (8%)	26,578 (7%)	54,550 (8%)	0.50	0.70
T > C	5764 (14%)	80,644 (13%)	47,058 (13%)	86,408 (13%)	0.68	0.41
T > G	3898 (9%)	50,366 (8%)	29,430 (8%)	54,264 (8%)	0.56	0.67

Frequency and proportion of mutation types among young-onset (diagnosed at ≤40 years of age, n = 89), older-onset (diagnosed at > 40 years of age, n = 949), and oldest-onset (diagnosed at > 60 years of age, n = 465) breast tumours. Entries are number of mutations (% of SNVs in age group). The p-values were calculated using a Welch Two Sample t-test (* indicates statistical significance at the 0.05 level). SNV: Single Nucleotide Variant

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