From: Mutational landscape differences between young-onset and older-onset breast cancer patients
Gene | Young | Older | Oldest | p-value (young vs. older) | p-value (young vs. oldest) |
---|---|---|---|---|---|
TP53 | 31(34%) | 320(33.6%) | 133(28.6%) | 0.91 | 0.32 |
PIK3CA | 22(24%) | 340(35.7%) | 174(37.4%) | 0.03* | 0.02* |
GATA3 | 20(22%) | 123(12.9%) | 50(10.8%) | 0.02* | 0.01* |
TAF1 | 9(10%) | 73(7.7%) | 40(8.6%) | 0.42 | 0.69 |
PTEN | 7(8%) | 58(6.1%) | 32(6.9%) | 0.50 | 0.82 |
NF1 | 6(7%) | 97(10.2%) | 57(12.3%) | 0.36 | 0.15 |
ATM | 6(7%) | 70(7.4%) | 35(7.5%) | 1.00 | 1.00 |
MORC4 | 6(7%) | 59(6.2%) | 29(6.2%) | 0.82 | 0.82 |
ARID1A | 6(7%) | 58(6.1%) | 27(5.8%) | 0.82 | 0.81 |
NIPBL | 5(5%) | 66(6.9%) | 38(8.2%) | 0.83 | 0.52 |
CTNNB1 | 5(5%) | 14(1.5%) | 10(2.2%) | 0.02* | 0.08 |
CDH1 | 4(4%) | 170(17.9%) | 96(20.6%) | 0.0003* | 0.0001* |
PIK3R1 | 4(4%) | 58(6.1%) | 35(7.5%) | 0.65 | 0.37 |
MAP2K4 | 4(4%) | 53(5.6%) | 26(5.6%) | 0.81 | 0.80 |
RB1 | 4(4%) | 49(5.1%) | 23(4.9%) | 1.00 | 1.00 |
PPP2R1A | 4(4%) | 34(3.6%) | 23(4.9%) | 0.57 | 1.00 |
AKT1 | 4(4%) | 32(3.4%) | 14(3%) | 0.55 | 0.51 |
MAP3K1 | 3(3%) | 108(11.3%) | 66(14.2%) | 0.01* | 0.003* |
BRCA1 | 3(3%) | 47(4.9%) | 26(5.6%) | 0.61 | 0.60 |
CHD4 | 3(3%) | 47(4.9%) | 28(6%) | 0.61 | 0.45 |
EP300 | 3(3%) | 40(4.2%) | 20(4.3%) | 1.00 | 1.00 |
HCFC2 | 3(3%) | 19(2%) | 10(2.2%) | 0.43 | 0.46 |
RPL22 | 3(3%) | 13(1.4%) | 9(1.9%) | 0.16 | 0.43 |
RUNX1 | 2(2%) | 62(6.5%) | 33(7.1%) | 0.11 | 0.10 |
FBXW7 | 2(2%) | 33(3.5%) | 16(3.4%) | 0.76 | 0.75 |
ZC3H13 | 2(2%) | 32(3.4%) | 17(3.7%) | 0.76 | 0.75 |
RASA1 | 2(2%) | 31(3.3%) | 16(3.4%) | 1.00 | 0.75 |
CTCF | 2(2%) | 29(3%) | 14(3%) | 1.00 | 1.00 |
ACVR2A | 2(2%) | 28(2.9%) | 17(3.7%) | 1.00 | 0.75 |
ARID5B | 2(2%) | 26(2.7%) | 18(3.9%) | 1.00 | 0.76 |
SPOP | 2(2%) | 20(2.1%) | 7(1.5%) | 1.00 | 0.65 |
RNF43 | 2(2%) | 14(1.5%) | 11(2.4%) | 0.64 | 1.00 |
TBX3 | 1(1%) | 51(5.4%) | 27(5.8%) | 0.08 | 0.07 |
CCAR1 | 1(1%) | 30(3.2%) | 16(3.4%) | 0.51 | 0.33 |
CASP8 | 1(1%) | 26(2.7%) | 14(3%) | 0.50 | 0.48 |
LARP7 | 1(1%) | 21(2.2%) | 13(2.8%) | 0.71 | 0.49 |
CDKN1B | 1(1%) | 13(1.4%) | 6(1.3%) | 1.00 | 1.00 |
RPL5 | 1(1%) | 13(1.4%) | 11(2.4%) | 1.00 | 0.70 |
KRAS | 1(1%) | 12(1.3%) | 8(1.7%) | 1.00 | 1.00 |
CD3G | 1(1%) | 10(1.1%) | 5(1.1%) | 1.00 | 1.00 |
LATS1 | 1(1%) | 10(1.1%) | 6(1.3%) | 1.00 | 1.00 |
CCND1 | 1(1%) | 3(0.3%) | 1(0.2%) | 0.31 | 0.30 |
PIK3R3 | 0(0%) | 18(1.9%) | 12(2.6%) | 0.39 | 0.23 |
PRRG1 | 0(0%) | 13(1.4%) | 10(2.2%) | 0.62 | 0.38 |
B2M | 0(0%) | 8(0.8%) | 4(0.9%) | 1.00 | 1.00 |
AP1S1 | 0(0%) | 7(0.7%) | 5(1.1%) | 1.00 | 1.00 |