|
Age < 70 vs. ≥70
|
0.61
|
0.42–0.88
|
0.0083
|
0.64
|
0.43–0.95
|
0.026
|
|
Gender Male vs. Female
|
1.99
|
1.07–3.69
|
0.029
|
2.47
|
1.27–4.81
|
0.0080
|
|
ECOG Performance status 0–1 vs.2–3
|
0.31
|
0.17–0.55
|
< 0.001
|
0.94
|
0.461.93
|
0.87
|
|
BMI < 20 vs. ≥20
|
1.72
|
1.20–2.50
|
0.0043
|
1.53
|
1.03–2.28
|
0.035
|
|
Primary site Oropharynx vs. others
|
1.25
|
0.85–1.83
|
0.25
| | | |
|
T-classification 1–2 vs. 3–4
|
0.42
|
0.28–0.61
|
< 0.001
|
0.58
|
0.38–0.87
|
0.0087
|
|
N-classification 0-2b vs. 2c-3
|
0.50
|
0.34–0.74
|
< 0.001
|
0.55
|
0.37–0.84
|
0.0050
|
|
Histology SCC vs. others
|
2.06
|
0.84–5.06
|
0.11
| | | |
|
Brinkman index < 500 vs. ≥500
|
0.95
|
0.66–1.36
|
0.76
| | | |
|
Habitual alcoholic consumption Yes vs. No
|
1.22
|
0.85–1.72
|
0.29
| | | |
|
Use of ACEi or ARB Yes vs. No
|
0.97
|
0.63–1.49
|
0.88
| | | |
|
Use of PPI or H2 blocker Yes vs. No
|
1.20
|
0.85–1.72
|
0.30
| | | |
|
Oral hygiene before treatment Good vs. Poor
|
0.66
|
0.46–0.94
|
0.021
|
0.94
|
0.65–1.37
|
0.76
|
|
Coexistence of other malignancies Yes vs. No
|
1.16
|
0.90–1.52
|
0.24
| | | |
|
Charlson comorbidity index 0–1 vs. ≥2
|
0.62
|
0.41–0.92
|
0.018
|
0.72
|
0.47–1.11
|
0.14
|
|
Serum albumin before treatment Within normal limits vs. less than normal range
|
0.33
|
0.22–0.48
|
< 0.001
|
0.50
|
0.30–0.83
|
0.0069
|
|
Hemoglobin before treatment Within normal limits vs. less than normal range
|
0.58
|
0.40–0.83
|
0.0028
|
0.83
|
0.53–1.31
|
0.43
|
|
Use of sleeping pills before treatment Yes .vs No
|
2.00
|
1.39–2.86
|
< 0.001
|
1.16
|
0.73–1.85
|
0.54
|
|
Induction chemotherapy Yes vs. No
|
0.87
|
0.56–1.33
|
0.51
| | | |
|
Concurrent chemotherapy regimen CDDP vs. others
|
0.66
|
0.45–0.97
|
0.036
|
0.71
|
0.45–1.12
|
0.14
|
|
Radiation technique Conventional 3D-CRT vs. IMRT
|
1.26
|
0.83–1.92
|
0.27
| | | |
|
Radiation dose 70Gy vs. <70Gy
|
0.25
|
0.12–0.50
|
< 0.001
|
0.18
|
0.084–0.40
|
< 0.001
|
|
Irradiation field Local vs. whole neck
|
0.90
|
0.56–1.43
|
0.66
| | | |
|
Percutaneous endoscopic gastrostomy prior to treatment Yes vs. No
|
1.76
|
1.21–2.56
|
0.0034
|
1.16
|
0.78–1.73
|
0.47
|
|
Treatment Inpatient vs. Outpatient
|
1.77
|
1.24–2.53
|
0.0018
|
1.47
|
0.99–2.17
|
0.052
|
|
The worst mucositis grade during treatment 1–2 vs. 3–4
|
0.98
|
0.68–1.40
|
0.90
| | | |
|
The worst dysphagia score during treatment 1–2 vs. 3–4
|
0.92
|
0.64–1.31
|
0.63
| | | |
|
Aspiration pneumonia during treatment Yes vs. No
|
1.56
|
2.22–3.23
|
< 0.001
|
1.58
|
1.06–2.35
|
0.024
|
