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Fig. 2 | BMC Cancer

Fig. 2

From: Primary malignant pericardial tumour in Lynch syndrome

Fig. 2

Cardiac mass pathology. Macroscopic appearance of neoplastic mass within the pericardial specimen (A: white circle) and on transverse cuts (B, arrow). The histology macrosection (C) shows infiltration of pericardial tissue by malignant proliferation (arrows) and an extensive area of necrosis (asterisk). At higher magnification, pleomorphic spindle and epithelioid cells are evident (D-E: Haematoxylin-Eosin 100x) as are multinucleated cells (F: Haematoxylin-Eosin 400x). Immunohistochemistry showing diffuse, strong immunostaining for vimentin (G: 200x) and smooth muscle actin (H: 200x) and, in multifocal areas, for cytokeratin-7 (I: 200x)

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