Fig. 2

Gene dendrogram and module cluster for Histopathological feature. a Clustering dendrogram of genes, with dissimilarity based on topological overlap, is merged with assigned module colors and the original module colors. b The correlation of Module-clinical traits. Each row corresponds to a module; each column corresponds to a clinical trait feature. Each cell contains the test statistic value and its corresponding p value from the linear mixed-effects model. Network of eigengene represents the relationships among the modules and the histological traits. c There are total 6 Module memberships vs. gene significance cluster for histopathology trait. Module membership vs gene significance is correlating to thyroid nodule histopathological status. Panel d shows a hierarchical clustering dendrogram of the eigengenes in which the dissimilarity of eigengenes (EI, EJ is given by 1 − cor(EI, EJ). The heatmap in panel (e) shows the eigengene adjacency (AI J = (1 + cor (EI, EJ))/2)