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Table 3 Multivariate Logistic Regression Analysis of Demographic and Clinicopathological Characteristics Predictive of Lymph Node Metastasis in Thyroid Carcinoma Patients

From: Lymph node metastasis in young and middle-aged papillary thyroid carcinoma patients: a SEER-based cohort study

Variance

PTC

FTC

OR(95%CI)

P value

OR(95%CI)

P value

Age at diagnosis

0.974 (0.972–0.975)

<.0001

0.999 (0.988–1.009)

.82

Sex (female vs. male)

0.481 (0.456–0.507)

<.0001

0.569 (0.408–0.796)

.001

Race

 

<.0001

 

.02

 White

1 (reference)

 

1 (reference)

 

 Black

0.782 (0.695–0.881)

<.0001

1.010 (0.530–1.923)

.98

 API

1.191 (1.114–1.274)

<.0001

 AI/AN

1.714 (1.300–2.261)

<.0001

1.883 (1.193–2.971)

.007

Tumor size (mm)

 

<.0001

 

.51

 0–10

1 (reference)

 

1 (reference)

 

 11–20

1.821 (1.724–1.923)

<.0001

1.291 (0.629–2.652)

.49

 21–40

2.36 (2.224–2.504)

<.0001

0.934 (0.473–1.843)

.84

 >40

2.547 (2.329–2.784)

<.0001

0.952 (0.472–1.919)

.89

ETE

 

<.0001

 

<.0001

 Localized

1 (reference)

 

1 (reference)

 

 Minora

4.127 (3.805–4.478)

<.0001

6.627 (3.974–11.050)

<.0001

 Strap musclesb

3.509 (3.260–3.777)

<.0001

4.497 (2.621–7.715)

<.0001

 Major neck structuresc

7.575 (6.641–8.640)

<.0001

7.620 (4.580–12.676)

<.0001

Laterality

0.950 (0.714–1.265)

.73

1.00

Multifocality

1.661 (1.590–1.735)

<.0001

2.816 (2.012–3.941)

<.0001

Histology

 

<.0001

 

 Adenocarcinoma

1 (reference)

 

 

 Follicular variant

0.371 (0.353–0.391)

<.0001

 Oxyphilic cell variant

0.741 (0.470–1.168)

.20

 Encapsulated variant

0.312 (0.230–0.424)

<.0001

 Columnar cell variant

1.089 (0.913–1.298)

.34

 Microcarcinomad

0.338 (0.290–0.393)

<.0001

Distant metastasise

2.787 (2.137–3.635)

<.0001

3.768 (2.195–6.467)

<.0001

  1. Abbreviations: PTC Papillary thyroid carcinoma, FTC Follicular thyroid carcinoma, OR Odds ratio, CI Confidence interval, API Asian or Pacific Islander, AI/AN American Indian/Alaska Native, ETE Extrathyroidal extension
  2. Note: aPericapsular soft tissue/connective tissue; bsternohyoid, sternothyroid, thyrohyoid, or omohyoid muscles; cinvading subcutaneous soft tissues, larynx, trachea, esophagus, recurrent laryngeal nerve, prevertebral fascia, or encasing the carotid artery or mediastinal vessels; dlabeled as microcarcinoma in Surveillance, Epidemiology, and End Results (SEER) database, there was no specific pathological subtype classification; eincluding the bone, brain, liver, lung. Reference groups are male, white, tumor size≤10 mm, intrathyroidal tumors, one side tumors, single tumors, adenocarcinoma, and absence of distant metastasis. Number of observations: 45,346. Bolded font indicates statistical significance