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Table 2 The Distribution of Age at Diagnosis in Thyroid Carcinoma Patients according to Demographic and Clinicopathological Characteristics

From: Lymph node metastasis in young and middle-aged papillary thyroid carcinoma patients: a SEER-based cohort study

VariancePTCFTC
Mean ± SD, yearMedian (QR), yearP valueaMean ± SD, yearMedian (QR), yearP valuea
Sex  <.0001  <.0001
 Male48.6 ± 14.348 (20) 53.1 ± 14.554 (19) 
 Female45.0 ± 14.144 (20) 48.3 ± 16.048 (23) 
Race  <.0001  .12
 White45.8 ± 14.345 (20) 49.6 ± 15.750 (23) 
 Black46.6 ± 13.745 (19) 49.9 ± 15.050 (22) 
 API45.7 ± 14.145 (21)  
 AI/AN42.6 ± 14.540 (22) 49.9 ± 16.249 (24) 
 Unknown42.1 ± 13.341 (19) 42.5 ± 14.140 (23) 
Tumor size (mean ± SD),mm  <.0001  <.0001
 0–1047.3 ± 13.347 (19) 48.6 ± 13.950 (19) 
 11–2045.1 ± 13.744 (20) 47.9 ± 14.947 (21) 
 21–4044.5 ± 15.043 (22) 47.9 ± 15.148 (23) 
 >4046.0 ± 16.344 (24) 52.9 ± 16.753 (26) 
 Unknown47 ± 15.246 (22) 51.5 ± 16.653 (27) 
ETE  <.0001  <.0001
 Localized45.1 ± 13.844 (20) 47.9 ± 15.148 (23) 
 Minorb46.3 ± 14.746 (21) 57.8 ± 16.457.5 (23) 
 Strap musclesc46.5 ± 14.746 (22) 53.5 ± 16.855 (26) 
 Major neck structuresd53.2 ± 16.753 (26) 61.3 ± 14.363 (17) 
 Unknown47.1 ± 15.147 (23) 60.0 ± 15.359 (24) 
Laterality  .49  .72
 One side45.8 ± 14.245 (20) 49.6 ± 15.750 (23) 
 Bilateral46.4 ± 14.545 (21) 52.5 ± 19.548.5 (33) 
Multifocality  .01  <.0001
 Absent45.6 ± 14.545 (21) 49.1 ± 15.749 (23) 
 Present45.9 ± 13.945 (20) 50.9 ± 15.451 (21) 
 Unknown46.4 ± 15.145.5 (21) 57.5 ± 15.957 (24) 
Histological Variant  <.0001  
 Adenocarcinoma44.9 ± 14.344 (21)  
 Follicular variant47.3 ± 13.947 (20)  
 Oxyphilic cell variant47.6 ± 15.548.5 (23)  
 Encapsulated variant46.0 ± 12.845 (19)  
 Columnar cell variant50.5 ± 15.550 (23)  
 Microcarcinomae47.7 ± 13.048 (19)  
 Unknown45.0 ± 14.244 (20)  
T Stage  <.0001  <.0001
 T1a47.2 ± 13.247 (19) 48.8 ± 13.950 (18) 
 T1b44.7 ± 13.644 (19) 47.5 ± 15.047 (21) 
 T243.5 ± 14.542 (21) 47.3 ± 14.947 (22) 
 T345.6 ± 15.045 (22) 51.7 ± 16.652 (26) 
 T453.2 ± 16.753 (26) 61.3 ± 14.363 (17) 
 Unknown45.6 ± 14.645 (21) 50.4 ± 17.051 (27) 
Lymph node metastasis  <.0001  <.0001
 Negative47.4 ± 13.647 (20) 48.8 ± 15.549 (23) 
 Positive43.8 ± 14.742 (22) 55.3 ± 16.356 (24) 
Distant metastasisf  <.0001  <.0001
 No45.7 ± 14.145 (20) 48.8 ± 15.449 (23) 
 Yes55.6 ± 17.258 (24) 64.9 ± 13.067 (17) 
 Unknown43.9 ± 14.943 (22) 49.7 ± 16.948.5 (31) 
Total45.8 ± 14.245 (20) 49.6 ± 15.750 (23) 
  1. Abbreviations: PTC Papillary thyroid carcinoma, FTC Follicular thyroid carcinoma, SD Standard deviation, QR Quartile, API Asian or Pacific Islander, AI/AN American Indian/Alaska Native, ETE Extrathyroidal extension
  2. Note: aP value was calculated by Wilcoxon rank sum tests or by Kruskal-Wallis H test; bPericapsular soft tissue/connective tissue; csternohyoid, sternothyroid, thyrohyoid, or omohyoid muscles; d invading subcutaneous soft tissues, larynx, trachea, esophagus, recurrent laryngeal nerve, prevertebral fascia, or encasing the carotid artery or mediastinal vessels; elabeled as microcarcinoma in Surveillance, Epidemiology, and End Results (SEER) database, there was no specific pathological subtype classification; fincluding the bone, brain, liver, and lung. Number of observations: 50,347