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Table 2 The Distribution of Age at Diagnosis in Thyroid Carcinoma Patients according to Demographic and Clinicopathological Characteristics

From: Lymph node metastasis in young and middle-aged papillary thyroid carcinoma patients: a SEER-based cohort study

Variance

PTC

FTC

Mean ± SD, year

Median (QR), year

P valuea

Mean ± SD, year

Median (QR), year

P valuea

Sex

  

<.0001

  

<.0001

 Male

48.6 ± 14.3

48 (20)

 

53.1 ± 14.5

54 (19)

 

 Female

45.0 ± 14.1

44 (20)

 

48.3 ± 16.0

48 (23)

 

Race

  

<.0001

  

.12

 White

45.8 ± 14.3

45 (20)

 

49.6 ± 15.7

50 (23)

 

 Black

46.6 ± 13.7

45 (19)

 

49.9 ± 15.0

50 (22)

 

 API

45.7 ± 14.1

45 (21)

 

 

 AI/AN

42.6 ± 14.5

40 (22)

 

49.9 ± 16.2

49 (24)

 

 Unknown

42.1 ± 13.3

41 (19)

 

42.5 ± 14.1

40 (23)

 

Tumor size (mean ± SD),mm

  

<.0001

  

<.0001

 0–10

47.3 ± 13.3

47 (19)

 

48.6 ± 13.9

50 (19)

 

 11–20

45.1 ± 13.7

44 (20)

 

47.9 ± 14.9

47 (21)

 

 21–40

44.5 ± 15.0

43 (22)

 

47.9 ± 15.1

48 (23)

 

 >40

46.0 ± 16.3

44 (24)

 

52.9 ± 16.7

53 (26)

 

 Unknown

47 ± 15.2

46 (22)

 

51.5 ± 16.6

53 (27)

 

ETE

  

<.0001

  

<.0001

 Localized

45.1 ± 13.8

44 (20)

 

47.9 ± 15.1

48 (23)

 

 Minorb

46.3 ± 14.7

46 (21)

 

57.8 ± 16.4

57.5 (23)

 

 Strap musclesc

46.5 ± 14.7

46 (22)

 

53.5 ± 16.8

55 (26)

 

 Major neck structuresd

53.2 ± 16.7

53 (26)

 

61.3 ± 14.3

63 (17)

 

 Unknown

47.1 ± 15.1

47 (23)

 

60.0 ± 15.3

59 (24)

 

Laterality

  

.49

  

.72

 One side

45.8 ± 14.2

45 (20)

 

49.6 ± 15.7

50 (23)

 

 Bilateral

46.4 ± 14.5

45 (21)

 

52.5 ± 19.5

48.5 (33)

 

Multifocality

  

.01

  

<.0001

 Absent

45.6 ± 14.5

45 (21)

 

49.1 ± 15.7

49 (23)

 

 Present

45.9 ± 13.9

45 (20)

 

50.9 ± 15.4

51 (21)

 

 Unknown

46.4 ± 15.1

45.5 (21)

 

57.5 ± 15.9

57 (24)

 

Histological Variant

  

<.0001

  

 Adenocarcinoma

44.9 ± 14.3

44 (21)

 

 

 Follicular variant

47.3 ± 13.9

47 (20)

 

 

 Oxyphilic cell variant

47.6 ± 15.5

48.5 (23)

 

 

 Encapsulated variant

46.0 ± 12.8

45 (19)

 

 

 Columnar cell variant

50.5 ± 15.5

50 (23)

 

 

 Microcarcinomae

47.7 ± 13.0

48 (19)

 

 

 Unknown

45.0 ± 14.2

44 (20)

 

 

T Stage

  

<.0001

  

<.0001

 T1a

47.2 ± 13.2

47 (19)

 

48.8 ± 13.9

50 (18)

 

 T1b

44.7 ± 13.6

44 (19)

 

47.5 ± 15.0

47 (21)

 

 T2

43.5 ± 14.5

42 (21)

 

47.3 ± 14.9

47 (22)

 

 T3

45.6 ± 15.0

45 (22)

 

51.7 ± 16.6

52 (26)

 

 T4

53.2 ± 16.7

53 (26)

 

61.3 ± 14.3

63 (17)

 

 Unknown

45.6 ± 14.6

45 (21)

 

50.4 ± 17.0

51 (27)

 

Lymph node metastasis

  

<.0001

  

<.0001

 Negative

47.4 ± 13.6

47 (20)

 

48.8 ± 15.5

49 (23)

 

 Positive

43.8 ± 14.7

42 (22)

 

55.3 ± 16.3

56 (24)

 

Distant metastasisf

  

<.0001

  

<.0001

 No

45.7 ± 14.1

45 (20)

 

48.8 ± 15.4

49 (23)

 

 Yes

55.6 ± 17.2

58 (24)

 

64.9 ± 13.0

67 (17)

 

 Unknown

43.9 ± 14.9

43 (22)

 

49.7 ± 16.9

48.5 (31)

 

Total

45.8 ± 14.2

45 (20)

 

49.6 ± 15.7

50 (23)

 
  1. Abbreviations: PTC Papillary thyroid carcinoma, FTC Follicular thyroid carcinoma, SD Standard deviation, QR Quartile, API Asian or Pacific Islander, AI/AN American Indian/Alaska Native, ETE Extrathyroidal extension
  2. Note: aP value was calculated by Wilcoxon rank sum tests or by Kruskal-Wallis H test; bPericapsular soft tissue/connective tissue; csternohyoid, sternothyroid, thyrohyoid, or omohyoid muscles; d invading subcutaneous soft tissues, larynx, trachea, esophagus, recurrent laryngeal nerve, prevertebral fascia, or encasing the carotid artery or mediastinal vessels; elabeled as microcarcinoma in Surveillance, Epidemiology, and End Results (SEER) database, there was no specific pathological subtype classification; fincluding the bone, brain, liver, and lung. Number of observations: 50,347