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Table 4 Indirect comparison in ORR

From: Efficacy of bevacizumab combined with chemotherapy in the treatment of HER2-negative metastatic breast cancer: a network meta-analysis

A

0.21 (0.051, 0.85)

2.06 (1.20, 2.81)

0.72 (0.35, 1.5)

0.87 (0.28, 2.8)

1.4 (0.67, 2.8)

2.5 (1.3, 4.9)

1.1 (0.37, 3.3)

1.1 (0.37, 3.5)

2.0 (0.62, 6.2)

2.5 (0.77, 8.2)

4.7 (1.2, 20.0)

B

7.1 (1.9, 28.0)

3.4 (1.0, 12.0)

4.1 (0.71, 24.0)

6.5 (1.4, 31.0)

12.0 (2.8, 52.0)

5.2 (0.96, 29.0)

5.4 (1.3, 24.0)

9.3 (1.7, 53.0)

12.0 (2.1, 69.0)

0.49 (0.36, 0.83)

0.14 (0.036, 0.53)

C

0.48 (0.26, 0.88)

0.58 (0.19, 1.7)

0.92 (0.45, 1.9)

1.7 (0.95, 2.9)

0.73 (0.26, 2.0)

0.76 (0.26, 2.2)

1.3 (0.44, 3.9)

1.7 (0.54, 5.1)

1.4 (0.68, 2.8)

0.30 (0.085, 0.96)

2.1 (1.1, 3.9)

D

1.2 (0.34, 4.2)

1.9 (0.74, 4.9)

3.5 (1.5, 8.0)

1.5 (0.46, 5.1)

1.6 (0.67, 3.8)

2.7 (0.78, 9.7)

3.5 (0.96, 12.0)

1.2 (0.36, 3.6)

0.24 (0.042, 1.4)

1.7 (0.58, 5.2)

0.82 (0.24, 2.9)

E

1.6 (0.42, 5.9)

2.9 (0.83, 9.9)

1.3 (0.28, 5.6)

1.3 (0.28, 6.1)

2.3 (0.48, 11.0)

2.8 (0.60, 14.0)

0.72 (0.35, 1.5)

0.15 (0.032, 0.70)

1.1 (0.53, 2.2)

0.52 (0.20, 1.3)

0.63 (0.17, 2.4)

F

1.8 (0.73, 4.6)

0.80 (0.23, 2.8)

0.82 (0.23, 3.0)

1.4 (0.39, 5.2)

1.8 (0.48, 6.8)

0.40 (0.20, 0.78)

0.085 (0.019, 0.36)

0.60 (0.34, 1.1)

0.29 (0.12, 0.66)

0.35 (0.10, 1.2)

0.56 (0.22, 1.4)

G

0.44 (0.14, 1.4)

0.46 (0.14, 1.5)

0.79 (0.23, 2.7)

0.99 (0.28, 3.5)

0.91 (0.30, 2.7)

0.19 (0.034, 1.0)

1.4 (0.49, 3.8)

0.65 (0.20, 2.2)

0.79 (0.18, 3.5)

1.3 (0.36, 4.4)

2.3 (0.70, 7.4)

H

1.0 (0.24, 4.5)

1.8 (0.40, 8.1)

2.2 (0.49, 10.0)

0.88 (0.29, 2.7)

0.19 (0.042, 0.80)

1.3 (0.46, 3.8)

0.63 (0.27, 1.5)

0.77 (0.16, 3.5)

1.2 (0.34, 4.3)

2.2 (0.66, 7.3)

0.97 (0.22, 4.2)

I

1.7 (0.37, 8.0)

2.2 (0.47, 10.0)

0.51 (0.16, 1.6)

0.11 (0.019, 0.61)

0.76 (0.25, 2.3)

0.37 (0.10, 1.3)

0.44 (0.094, 2.1)

0.70 (0.19, 2.6)

1.3 (0.37, 4.4)

0.56 (0.12, 2.5)

0.58 (0.12, 2.7)

J

1.3 (0.26, 6.1)

0.40 (0.12, 1.3)

0.085 (0.014, 0.48)

0.60 (0.20, 1.8)

0.29 (0.080, 1.0)

0.35 (0.073, 1.7)

0.56 (0.15, 2.1)

1.0 (0.28, 3.5)

0.45 (0.097, 2.0)

0.46 (0.097, 2.1)

0.79 (0.16, 3.9)

K

  1. A = Tax, B = Cap, C = Bev + Tax, D = Bev + Cap, E = Bev + Exm, F = Mot + Tax, G = Bev + Tax+Cap, H = Bev + Cap+Cyc, I = Bev + Cap+Vin, J = Bev + Tax+ Eve, K = Bev + Tax+Tre
  2. The values represent OR (95%CI), and the values in bold represent OR (95%CI) has significant statistical difference in indirect comparison
  3. Bev bevacizumab, Cap capecitabine, Tax taxanes, Vin vinorelbine, Cyc cyclophosphamide, Exm exemestane, Eve everolimus, Tre trebananib, Mot motesanib
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