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Table 3 Indirect comparison in PFS

From: Efficacy of bevacizumab combined with chemotherapy in the treatment of HER2-negative metastatic breast cancer: a network meta-analysis

A

1.2 (0.46, 3.1)

0.65 (0.48, 0.88)

0.87 (0.50, 1.5)

0.65 (0.29, 1.5)

0.91 (0.45, 1.8)

0.38 (0.23, 0.65)

0.78 (0.37, 1.6)

0.73 (0.30, 1.8)

0.63 (0.27, 1.5)

0.63 (0.27, 1.5)

0.84 (0.33, 2.2)

B

0.55 (0.22, 1.3)

0.73 (0.34, 1.6)

0.54 (0.17, 1.8)

0.76 (0.24, 2.4)

0.32 (0.12, 0.87)

0.66 (0.22, 2.0)

0.61 (0.22, 1.7)

0.53 (0.16, 1.7)

0.53 (0.16, 1.8)

1.5 (1.1, 2.1)

1.8 (0.75, 4.5)

C

1.3 (0.83, 2.2)

1.0 (0.47, 2.2)

1.4 (0.67, 2.8)

0.59 (0.39, 0.91)

1.2 (0.61, 2.4)

1.1 (0.49, 2.6)

0.97 (0.44, 2.2)

0.98 (0.43, 2.2)

1.1 (0.65, 2.0)

1.4 (0.64, 2.9)

0.75 (0.46, 1.2)

D

0.74 (0.31, 1.8)

1.0 (0.44, 2.5)

0.44 (0.23, 0.83)

0.90 (0.38, 2.0)

0.84 (0.43, 1.7)

0.73 (0.28, 1.9)

0.73 (0.28, 1.8)

1.5 (0.67, 3.4)

1.8 (0.57, 5.9)

1.0 (0.46, 2.1)

1.3 (0.54, 3.3)

E

1.4 (0.49, 4.0)

0.59 (0.24, 1.4)

1.2 (0.43, 3.3)

1.1 (0.36, 3.5)

0.97 (0.32, 3.0)

0.98 (0.32, 3.0)

1.1 (0.55, 2.2)

1.3 (0.42, 4.2)

0.72 (0.35, 1.5)

0.96 (0.41, 2.3)

0.71 (0.25, 2.0)

F

0.42 (0.18, 0.99)

0.86 (0.32, 2.3)

0.81 (0.27, 2.5)

0.70 (0.24, 2.1)

0.70 (0.24, 2.1)

2.6 (1.5, 4.4)

3.1 (1.2, 8.3)

1.7 (1.1, 2.6)

2.3 (1.2, 4.3)

1.7 (0.71, 4.1)

2.4 (1.0, 5.4)

G

2.1 (0.90, 4.5)

1.9 (0.75, 4.9)

1.7 (0.67, 4.0)

1.7 (0.66, 4.1)

1.3 (0.61, 2.7)

1.5 (0.50, 4.6)

0.83 (0.42, 1.7)

1.1 (0.49, 2.6)

0.83 (0.30, 2.3)

1.2 (0.43, 3.1)

0.49 (0.22, 1.1)

H

0.94 (0.32, 2.8)

0.81 (0.29, 2.3)

0.81 (0.28, 2.3)

1.4 (0.55, 3.3)

1.6 (0.59, 4.5)

0.89 (0.38, 2.0)

1.2 (0.60, 2.3)

0.88 (0.28, 2.8)

1.2 (0.41, 3.7)

0.52 (0.20, 1.3)

1.1 (0.36, 3.1)

I

0.86 (0.27, 2.7)

0.87 (0.26, 2.8)

1.6 (0.67, 3.7)

1.9 (0.58, 6.3)

1.0 (0.46, 2.3)

1.4 (0.54, 3.5)

1.0 (0.34, 3.1)

1.4 (0.48, 4.2)

0.61 (0.25, 1.5)

1.2 (0.43, 3.5)

1.2 (0.37, 3.6)

J

1.0 (0.32, 3.1)

1.6 (0.66, 3.7)

1.9 (0.57, 6.4)

1.0 (0.46, 2.3)

1.4 (0.55, 3.6)

1.0 (0.34, 3.1)

1.4 (0.48, 4.2)

0.60 (0.24, 1.5)

1.2 (0.43, 3.5)

1.2 (0.36, 3.8)

1.0 (0.32, 3.1)

K

  1. A = Tax, B = Cap, C = Bev + Tax, D = Bev + Cap, E = Bev + Exm, F = Mot + Tax, G = Bev + Tax+Cap, H = Bev + Cap+Cyc, I = Bev + Cap+Vin, J = Bev + Tax+ Eve, K = Bev + Tax+Tre
  2. The values represent HR (95%CI), and the values in bold represent HR (95%CI) has significant statistical difference in indirect comparison
  3. Bev bevacizumab, Cap capecitabine, Tax taxanes, Vin vinorelbine, Cyc cyclophosphamide, Exm exemestane, Eve everolimus, Tre trebananib, Mot motesanib