From: Combination versus single-agent as palliative chemotherapy for gastric cancer
Prognostic Factors | Before propensity score matching | After propensity score matching | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | |||||||
MS (months) | P valuea | HR | 95% CI | P valueb | MS (months) | P valuea | HR | 95% CI | P valueb | |
Gender | 0.728 | 0.688 | ||||||||
Male | 10 | 9 | ||||||||
Female | 10 | 8 | ||||||||
Age (years) | 0.012 | 0.565 | ||||||||
< 70 | 11 | 1 | 9 | |||||||
≥ 70 | 8 | 1.01 | 0.80–1.27 | 0.941 | 9 | |||||
PS (ECOG) | < 0.0001 | < 0.0001 | ||||||||
0, 1 | 11 | 1 | 1 | 10 | 1 | 1 | ||||
≥ 2 | 5 | 1.47 | 1.13–1.92 | 0.004 | 5 | 1.59 | 1.10–2.28 | 0.013 | ||
Disease status | 0.315 | 0.336 | ||||||||
Primary metastatic | 10 | 8 | ||||||||
Recurrent | 10 | 10 | ||||||||
Tumor differentiation | 0.022 | 0.215 | ||||||||
Well, moderate | 12 | 1 | 11 | |||||||
Poor | 10 | 1.32 | 1.06–1.65 | 0.015 | 9 | |||||
Signet ring cell | 8 | 1.64 | 1.30–2.07 | < 0.0001 | 7 | |||||
Combined, others | 11 | 1.21 | 0.96–1.53 | 0.102 | 12 | |||||
Peritoneal metastasis | 0.001 | 0.037 | ||||||||
No | 11 | 1 | 10 | 1 | ||||||
Yes | 9 | 1.19 | 1.01–1.40 | 0.040 | 7 | 1.25 | 0.96–1.64 | 0.099 | ||
Liver metastasis | 0.595 | 0.613 | ||||||||
No | 11 | 9 | ||||||||
Yes | 9 | 9 | ||||||||
Palliative resection | < 0.0001 | < 0.0001 | ||||||||
No | 9 | 1 | 8 | 1 | ||||||
Yes | 19 | 0.42 | 0.34–0.52 | < 0.0001 | 15 | 0.59 | 0.41–0.85 | 0.005 | ||
1st line CTx | < 0.0001 | 0.322 | ||||||||
Single-agent | 8 | 1 | 8 | |||||||
Combination | 11 | 0.82 | 0.66–1.02 | 0.069 | 10 | |||||
CTx lines | < 0.0001 | < 0.0001 | ||||||||
1st line CTx | 6 | 1 | 6 | 1 | ||||||
≥ 2nd line CTx | 14 | 0.69 | 0.59–0.82 | < 0.0001 | 13 | 0.59 | 0.45–0.77 | < 0.0001 | ||
NLR | < 0.0001 | 0.013 | ||||||||
Low | 13 | 1 | 10 | 1 | ||||||
High | 8 | 1.35 | 1.14–1.61 | 0.001 | 7 | 1.25 | 0.95–1.65 | 0.111 | ||
PLR | < 0.0001 | 0.539 | ||||||||
Low | 12 | 1 | 9 | |||||||
High | 9 | 1.21 | 1.02–1.44 | 0.033 | 8 |