Table 2 Patients characteristics according to neutrophil-to-lymphocyte ratio /platelet-to-lymphocyte ratio
From: Combination versus single-agent as palliative chemotherapy for gastric cancer
Characteristics | Total N (%) | NLR | P value | PLR | P value | ||
|---|---|---|---|---|---|---|---|
Low | Higha | Low | Highb | ||||
Gender | 0.116 | 0.562 | |||||
Male | 478 (69.6) | 229 (66.8) | 249 (72.4) | 243 (70.6) | 235 (68.5) | ||
Female | 209 (30.4) | 114 (33.2) | 95 (27.6) | 101 (29.4) | 108 (31.5) | ||
Age (years) | 0.375 | 0.235 | |||||
< 70 | 562 (81.8) | 276 (80.5) | 286 (83.1) | 275 (79.9) | 287 (83.7) | ||
≥ 70 | 125 (18.2) | 67 (19.5) | 58 (16.9) | 69 (20.1) | 56 (16.3) | ||
PS (ECOG) | 0.020 | 0.333 | |||||
0, 1 | 611 (88.9) | 315 (91.8) | 296 (86.0) | 310 (90.1) | 301 (87.8) | ||
2, 3 | 76 (11.1) c | 28 (8.2) | 48 (14.0) | 34 (9.9) | 42 (12.2) | ||
Disease status | < 0.0001 | < 0.0001 | |||||
Primary metastatic | 383 (55.7) | 155 (45.2) | 228 (66.3) | 166 (48.3) | 217 (63.3) | ||
Recurrent | 304 (44.3) | 188 (54.8) | 116 (33.7) | 178 (51.7) | 126 (36.7) | ||
Tumor differentiation | 0.166 | 0.777 | |||||
Well, moderate | 167 (24.3) | 92 (26.8) | 75 (21.8) | 88 (25.6) | 79 (23.0) | ||
Poor | 186 (27.1) | 83 (24.2) | 103 (29.9) | 95 (27.6) | 91 (26.5) | ||
Signet ring cell | 171 (24.9) | 81 (23.6) | 90 (26.2) | 81 (23.5) | 90 (26.2) | ||
Combined, others | 163 (23.7) | 87 (25.4) | 76 (22.1) | 80 (23.3) | 83 (24.2) | ||
Peritoneal metastasis | 0.039 | < 0.0001 | |||||
No | 373 (54.3) | 200 (58.3) | 173 (50.3) | 220 (64.0) | 153 (44.6) | ||
Yes | 314 (45.7) | 143 (41.7) | 171(49.7) | 124 (36.0) | 190 (55.4) | ||
Liver metastasis | 1.000 | 0.004 | |||||
No | 535 (77.9) | 267 (77.8) | 268 (77.9) | 252 (73.3) | 283 (82.5) | ||
Yes | 152 (22.1) | 76 (22.2) | 76 (22.1) | 92 (26.7) | 60 (17.5) | ||
1st line CTx | 0.286 | 0.929 | |||||
Single-agent | 166 (24.2) | 89 (25.9) | 77 (22.4) | 84 (24.4) | 82 (23.9) | ||
Combination | 521 (75.8) | 254 (74.1) | 267 (77.6) | 260 (75.6) | 261 (76.1) | ||
Palliative surgical resection | < 0.0001 | 0.775 | |||||
No | 549 (79.9) | 250 (72.9) | 299 (86.9) | 273 (79.4) | 276 (80.5) | ||
Yes | 138 (20.1) | 93 (27.1) | 45 (13.1) | 71 (20.6) | 67 (19.5) | ||
PLR | < 0.0001 | – | |||||
Low | 344 (50.1) | 248 (72.3) | 96 (27.9) | – | – | ||
High | 343 (49.9) | 95 (27.7) | 248 (72.1) | – | – | ||