Table 1 Patients characteristics at the initiation of first-line chemotherapy
From: Combination versus single-agent as palliative chemotherapy for gastric cancer
Characteristics | Before propensity score matching | P value | After propensity score matching | P value | ||||
|---|---|---|---|---|---|---|---|---|
Total N (%) | Chemotherapy | Total N (%) | Chemotherapy | |||||
Single-agent | Combination | Single-agent | Combination | |||||
Gender | 0.101 | 0.672 | ||||||
Male | 478 (69.6) | 107(64.5) | 371 (71.2) | 164 (69.5) | 80(67.8) | 84 (71.2) | ||
Female | 209 (30.4) | 59 (35.5) | 150 (28.8) | 72 (30.5) | 38 (32.2) | 34 (28.8) | ||
Age (years) | < 0.0001 | 0.88 | ||||||
< 70 | 562 (81.8) | 94 (56.6) | 468 (89.8) | 160 (67.8) | 79 (66.9) | 81 (68.6) | 9 | |
≥ 70 | 125 (18.2) | 72 (43.4) | 53 (10.2) | 76 (32.2) | 39 (33.1) | 37 (31.4) | ||
PS (ECOG) | < 0.0001 | 0.865 | ||||||
0, 1 | 611 (88.9) | 116 (69.9) | 495 (95.0) | 194 (82.2) | 98 (83.1) | 96 (81.4) | ||
2, 3 | 76 (11.1)a | 50 (30.1) | 26 (5.0) | 42 (17.8)a | 20 (16.9) | 22 (18.6) | ||
Disease status | 0.325 | 0.696 | ||||||
Primary metastatic | 383 (55.7) | 87 (52.4) | 296 (56.8) | 116 (49.2) | 56 (47.5) | 60 (56.8) | ||
Recurrent | 304 (44.3) | 79 (47.6) | 225 (43.2) | 120 (50.8) | 62 (52.5) | 58 (49.2) | ||
Tumor differentiation | 0.111 | 0.933 | ||||||
Well, moderate | 167 (24.3) | 50 (30.1) | 117 (22.5) | 67 (28.4) | 34 (28.8) | 33 (28.0) | ||
Poor | 186 (27.1) | 43 (25.9) | 143 (27.4) | 61 (25.8) | 30 (25.4) | 31 (26.3) | ||
Signet ring cell | 171 (24.9) | 32 (19.3) | 139 (26.7) | 59 (25.0) | 28 (23.7) | 31 (26.3) | ||
Combined, others | 163 (23.7) | 41 (24.7) | 122 (23.4) | 49 (20.8) | 26 (22.0) | 23 (19.5) | ||
Peritoneal metastasis | 0.003 | 0.686 | ||||||
No | 373 (54.3) | 107 (64.5) | 266 (51.1) | 148 (62.7) | 72 (61.0) | 76 (64.4) | ||
Yes | 314 (45.7) | 59 (35.5) | 255 (48.9) | 88 (37.3) | 46 (39.0) | 42 (35.6) | ||
Liver metastasis | 0.915 | 0.382 | ||||||
No | 535 (77.9) | 130 (78.3) | 405 (77.7) | 171 (72.5) | 89 (75.4) | 82 (69.5) | ||
Yes | 152 (22.1) | 36 (21.7) | 116 (22.3) | 65 (27.5) | 29 (24.6) | 36 (30.5) | ||
Palliative surgical resection | 0.182 | 0.731 | ||||||
No | 549 (79.9) | 139 (83.7) | 410 (78.7) | 195 (82.6) | 96 (81.4) | 99 (83.9) | ||
Yes | 138 (20.1) | 27(16.3) | 111 (21.3) | 41 (17.4) | 22 (18.6) | 19 (16.1) | ||