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Table 4 Association between CYP2A6*4 and risk of developing cancer

From: Association of CYP2A6 gene deletion with cancers in Japanese elderly: an autopsy study

  Total subjectsMaleFemale
  WD + DD/WW (%)OR(95%CI)PP*WD + DD/WW (%)OR(95%CI)PP**WD + DD/WW (%)OR(95%CI)PP**
Total CA(n = 1373)204(37)/343(63)0.85 (0.68–1.06)0.1530.13292(34)/181(66)1.00 (0.73–1.37)0.9820.772112(41)/162(59)0.73 (0.52–1.01)0.0550.053
+277(34)/549(66)  158(34)/312(66)  119(33)/237(67)  
Gastric CA(n = 1372)429(35)/780(65)0.85 (0.60–1.21)0.3690.280210(33)/422(67)1.13 (0.74–1.73)0.5640.735219(38)/358(62)0.49 (0.25–0.95)0.0360.021
+52(32)/111(68)  40(36)/71(64)  12(23)/40(77)  
Colorectal CA(n = 1372)438(35)/804(65)0.91 (0.62–1.33)0.6190.716228(34)/447(66)0.94 (0.55–1.60)0.8130.772210(37)/357(63)0.87
(0.50–1.51)
0.6240.818
+43(33)/87(67)  22(32)/46(68)  21(34)/41(66)  
Lung CA(n = 1370)429(35)/813(65)1.30 (0.89–1.88)0.1710.097217(33)/443(67)1.35 (0.84–2.15)0.2120.178212(36)/370(64)1.28 (0.69–2.36)0.4380.322
+52(41)/76(59)  33(40)/50(60)  19(42)/26(58)  
Blood CA(n = 1371)428(34)/816(66)1.37 (0.94–1.98)0.1000.244214(32)/449(68)1.72 (1.07–2.75)0.0240.063214(37)/367(63)0.97 (0.52–1.80)0.9280.576
+53(42)/74(58)  36(45)/44(55)  17(36)/30(64)  
Smoking (n = 1288)223(35)/410(65)1.00 (0.79–1.25)0.966 63(34)/122(66)1.03 (0.73–1.47)0.853 160(36)/288(64)1.03 (0.69–1.53)0.902 
+230(35)/425(65)  181(35)/339(65)  49(36)/86(64)  
Alcohol (n = 1289)283(34)/550(66)1.16 (0.91–1.47)0.235 105(33)/212(67)1.15 (0.84–1.58)0.373 178(34)/338(66)1.41 (0.85–2.36)0.188 
+170(37)/286(63)  141(36)/247(64)  29(43)/39(57)  
  1. CA cancer; WW wild-type (reference); WD heterozygote; DD whole-gene deletion;-(cancer-free); + (cancer-bearing)
  2. * Represents adjusted by age, gender, smoking and drinking
  3. ** Represents adjusted by age, smoking and drinking