Table 4 Association between CYP2A6*4 and risk of developing cancer

WD + DD/WW (%)

OR(95%CI)

P

P*

WD + DD/WW (%)

OR(95%CI)

P

P**

WD + DD/WW (%)

OR(95%CI)

P

P**

Total CA(n = 1373)

–

204(37)/343(63)

0.85 (0.68–1.06)

0.153

0.132

92(34)/181(66)

1.00 (0.73–1.37)

0.982

0.772

112(41)/162(59)

0.73 (0.52–1.01)

0.055

0.053

+

277(34)/549(66)

158(34)/312(66)

119(33)/237(67)

Gastric CA(n = 1372)

–

429(35)/780(65)

0.85 (0.60–1.21)

0.369

0.280

210(33)/422(67)

1.13 (0.74–1.73)

0.564

0.735

219(38)/358(62)

0.49 (0.25–0.95)

0.036

0.021

+

52(32)/111(68)

40(36)/71(64)

12(23)/40(77)

Colorectal CA(n = 1372)

–

438(35)/804(65)

0.91 (0.62–1.33)

0.619

0.716

228(34)/447(66)

0.94 (0.55–1.60)

0.813

0.772

210(37)/357(63)

0.87

(0.50–1.51)

0.624

0.818

+

43(33)/87(67)

22(32)/46(68)

21(34)/41(66)

Lung CA(n = 1370)

–

429(35)/813(65)

1.30 (0.89–1.88)

0.171

0.097

217(33)/443(67)

1.35 (0.84–2.15)

0.212

0.178

212(36)/370(64)

1.28 (0.69–2.36)

0.438

0.322

+

52(41)/76(59)

33(40)/50(60)

19(42)/26(58)

Blood CA(n = 1371)

–

428(34)/816(66)

1.37 (0.94–1.98)

0.100

0.244

214(32)/449(68)

1.72 (1.07–2.75)

0.024

0.063

214(37)/367(63)

0.97 (0.52–1.80)

0.928

0.576

+

53(42)/74(58)

36(45)/44(55)

17(36)/30(64)

Smoking (n = 1288)

–

223(35)/410(65)

1.00 (0.79–1.25)

0.966

63(34)/122(66)

1.03 (0.73–1.47)

0.853

160(36)/288(64)

1.03 (0.69–1.53)

0.902

+

230(35)/425(65)

181(35)/339(65)

49(36)/86(64)

Alcohol (n = 1289)

–

283(34)/550(66)

1.16 (0.91–1.47)

0.235

105(33)/212(67)

1.15 (0.84–1.58)

0.373

178(34)/338(66)

1.41 (0.85–2.36)

0.188

+

170(37)/286(63)

141(36)/247(64)

29(43)/39(57)