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Table 1 Statistical significance of TMB in mutant and wildtype group of indicated genes in gliomas(n = 897)

From: Tumor mutational burden is associated with poor outcomes in diffuse glioma

 

Number of mutant group

Number of wildtype group

Median TMB of mutant group

Median TMB of wildtype group

P value

(Mann-Whitney test)

False discovery rate

(FDR)

Adjust p-value

(bonferroni)

IDH1

413

484

0.53

0.97

2.3E-58

4.6E-57

4.6E-57

TP53

317

580

0.67

0.81

5.5E-02

5.5E-02

1.0E+ 00

ATRX

203

694

0.61

0.81

1.2E-05

1.6E-05

2.4E-04

TTN

149

748

1.11

0.69

3.9E-20

3.9E-19

7.9E-19

PTEN

136

761

1.045

0.67

1.7E-18

1.2E-17

3.5E-17

CIC

106

791

0.47

0.78

1.4E-11

3.4E-11

2.7E-10

EGFR

89

808

1.08

0.69

2.1E-14

1.1E-13

4.3E-13

MUC16

74

823

1.06

0.72

5.6E-10

1.0E-09

1.1E-08

PIK3CA

74

823

0.92

0.72

1.4E-03

1.8E-03

2.9E-02

NF1

70

827

0.9

0.72

1.2E-02

1.4E-02

2.4E-01

PIK3R1

60

837

0.89

0.72

2.7E-02

2.9E-02

5.5E-01

RYR2

58

839

0.985

0.72

2.7E-02

2.9E-02

5.5E-01

FLG

57

840

1.33

0.72

1.8E-13

5.9E-13

3.6E-12

FUBP1

46

851

0.5

0.75

1.8E-13

5.9E-13

3.6E-12

SYNE1

45

852

4

0.72

6.8E-11

1.5E-10

1.4E-09

HMCN1

43

854

1.08

0.72

2.0E-08

3.0E-08

3.9E-07

PKHD1

42

855

1.14

0.72

2.6E-07

3.7E-07

5.2E-06

LRP2

41

856

1.25

0.72

1.2E-10

2.4E-10

2.4E-09

RB1

41

856

1.22

0.72

9.9E-09

1.7E-08

2.0E-07

SPTA1

41

856

1.25

0.72

3.0E-12

8.7E-12

6.1E-11