Fig. 3
From: Tumor mutational burden is associated with poor outcomes in diffuse glioma
TMBHigh gliomas exhibit increased proliferative activity and immune responses. a GO biological progress enriched by GSEA in the TMBHigh group (n = 302) versus the TMBLow group (n = 352) using an enrichment map. Node size represents the number of genes in the gene sets. Line width represents the number of overlapping genes. b Representative GSEA enrichment plots in (a). The NES (normalized enrichment score), p value and FDR (false discovery rate) were calculated with GSEA software. c GSEA of the validation set (CGGA) in the indicated gene sets. d The heatmap showing the distribution and correlation of the indicated gene set/genes in glioma specimens was visualized using Java Tree-view. Spearman’s r value and significance were calculated