TY - JOUR AU - Mateo, J. AU - Carreira, S. AU - Sandhu, S. AU - Miranda, S. AU - Mossop, H. AU - Perez-Lopez, R. PY - 2015 DA - 2015// TI - DNA-repair defects and olaparib in metastatic prostate cancer JO - N Engl J Med VL - 373 UR - https://doi.org/10.1056/NEJMoa1506859 DO - 10.1056/NEJMoa1506859 ID - Mateo2015 ER - TY - JOUR AU - Abida, W. AU - Campbell, D. AU - Patnaik, A. PY - 2019 DA - 2019// TI - Preliminary results from the TRITON2 study of rucaparib in patients (pts) with DNA damage repair (DDR)-deficient metastatic castration-resistant prostate cancer (mCRPC): Updated analyses JO - Ann Oncol VL - 30 ID - Abida2019 ER - TY - JOUR AU - Lin, K. K. AU - Harrell, M. I. AU - Oza, A. M. AU - Oaknin, A. AU - Ray-Coquard, I. AU - Tinker, A. V. PY - 2019 DA - 2019// TI - BRCA reversion mutations in circulating tumor DNA predict primary and acquired resistance to the PARP inhibitor rucaparib in high-grade ovarian carcinoma JO - Cancer Discov. VL - 9 UR - https://doi.org/10.1158/2159-8290.CD-18-0715 DO - 10.1158/2159-8290.CD-18-0715 ID - Lin2019 ER - TY - JOUR AU - Norquist, B. AU - Wurz, K. A. AU - Pennil, C. C. AU - Garcia, R. AU - Gross, J. AU - Sakai, W. PY - 2011 DA - 2011// TI - Secondary somatic mutations restoring BRCA1/2 predict chemotherapy resistance in hereditary ovarian carcinomas JO - J Clin Oncol VL - 29 UR - https://doi.org/10.1200/JCO.2010.34.2980 DO - 10.1200/JCO.2010.34.2980 ID - Norquist2011 ER - TY - JOUR AU - Goodall, J. AU - Mateo, J. AU - Yuan, W. AU - Mossop, H. AU - Porta, N. AU - Miranda, S. PY - 2017 DA - 2017// TI - Circulating cell-free DNA to guide prostate cancer treatment with PARP inhibition JO - Cancer Discov. VL - 7 UR - https://doi.org/10.1158/2159-8290.CD-17-0261 DO - 10.1158/2159-8290.CD-17-0261 ID - Goodall2017 ER - TY - JOUR AU - Quigley, D. AU - Alumkal, J. J. AU - Wyatt, A. W. AU - Kothari, V. AU - Foye, A. AU - Lloyd, P. PY - 2017 DA - 2017// TI - Analysis of circulating cell-free DNA identifies multiclonal heterogeneity of BRCA2 reversion mutations associated with resistance to PARP inhibitors JO - Cancer Discov VL - 7 UR - https://doi.org/10.1158/2159-8290.CD-17-0146 DO - 10.1158/2159-8290.CD-17-0146 ID - Quigley2017 ER - TY - JOUR AU - Carneiro, B. A. AU - Collier, K. A. AU - Nagy, R. J. AU - Pamarthy, S. AU - Sagar, V. AU - Fairclough, S. PY - 2018 DA - 2018// TI - Acquired resistance to poly (ADP-ribose) polymerase inhibitor olaparib in BRCA2-associated prostate cancer resulting from biallelic BRCA2 reversion mutations restores both germline and somatic loss-of-function mutations JO - JCO Precis Oncol VL - 2 ID - Carneiro2018 ER - TY - JOUR AU - Cheng, H. H. AU - Salipante, S. J. AU - Nelson, P. S. AU - Montgomery, B. AU - Pritchard, C. C. PY - 2018 DA - 2018// TI - Polyclonal BRCA2 reversion mutations detected in circulating tumor DNA after platinum chemotherapy in a patient with metastatic prostate cancer JO - JCO Precis Oncol VL - 2 ID - Cheng2018 ER - TY - JOUR AU - Frampton, G. M. AU - Fichtenholtz, A. AU - Otto, G. A. AU - Wang, K. AU - Downing, S. R. AU - He, J. PY - 2013 DA - 2013// TI - Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing JO - Nat Biotechnol VL - 31 UR - https://doi.org/10.1038/nbt.2696 DO - 10.1038/nbt.2696 ID - Frampton2013 ER - TY - JOUR AU - Clark, T. A. AU - Chung, J. H. AU - Kennedy, M. AU - Hughes, J. D. AU - Chennagiri, N. AU - Lieber, D. S. PY - 2018 DA - 2018// TI - Analytical validation of a hybrid capture-based next-generation sequencing clinical assay for genomic profiling of cell-free circulating tumor DNA JO - J Mol Diagn VL - 20 UR - https://doi.org/10.1016/j.jmoldx.2018.05.004 DO - 10.1016/j.jmoldx.2018.05.004 ID - Clark2018 ER - TY - JOUR AU - Shen, D. W. AU - Pouliot, L. M. AU - Hall, M. D. AU - Gottesman, M. M. PY - 2012 DA - 2012// TI - Cisplatin resistance: a cellular self-defense mechanism resulting from multiple epigenetic and genetic changes JO - Pharmacol Rev VL - 64 UR - https://doi.org/10.1124/pr.111.005637 DO - 10.1124/pr.111.005637 ID - Shen2012 ER - TY - JOUR AU - Carreira, A. AU - Kowalczykowski, S. C. PY - 2011 DA - 2011// TI - Two classes of BRC repeats in BRCA2 promote RAD51 nucleoprotein filament function by distinct mechanisms JO - Proc Natl Acad Sci U S A VL - 108 UR - https://doi.org/10.1073/pnas.1106971108 DO - 10.1073/pnas.1106971108 ID - Carreira2011 ER - TY - JOUR AU - Chatterjee, G. AU - Jimenez-Sainz, J. AU - Presti, T. AU - Nguyen, T. AU - Jensen, R. B. PY - 2016 DA - 2016// TI - Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity JO - Nucleic Acids Res VL - 44 UR - https://doi.org/10.1093/nar/gkw242 DO - 10.1093/nar/gkw242 ID - Chatterjee2016 ER - TY - JOUR AU - Zhao, R. AU - Choi, B. Y. AU - Lee, M. H. AU - Bode, A. M. AU - Dong, Z. PY - 2016 DA - 2016// TI - Implications of genetic and epigenetic alterations of CDKN2A (p16(INK4a)) in cancer JO - EBioMedicine. VL - 8 UR - https://doi.org/10.1016/j.ebiom.2016.04.017 DO - 10.1016/j.ebiom.2016.04.017 ID - Zhao2016 ER - TY - JOUR AU - Koh, J. AU - Enders, G. H. AU - Dynlacht, B. D. AU - Harlow, E. PY - 1995 DA - 1995// TI - Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition JO - Nature. VL - 375 UR - https://doi.org/10.1038/375506a0 DO - 10.1038/375506a0 ID - Koh1995 ER - TY - JOUR AU - Brown, V. L. AU - Harwood, C. A. AU - Crook, T. AU - Cronin, J. G. AU - Kelsell, D. P. AU - Proby, C. M. PY - 2004 DA - 2004// TI - p16INK4a and p14ARF tumor suppressor genes are commonly inactivated in cutaneous squamous cell carcinoma JO - J Invest Dermatol VL - 122 UR - https://doi.org/10.1111/j.0022-202X.2004.22501.x DO - 10.1111/j.0022-202X.2004.22501.x ID - Brown2004 ER - TY - STD TI - Helgadottir H, Ghiorzo P, van Doorn R, Puig S, Levin M, Kefford R, et al. Efficacy of novel immunotherapy regimens in patients with metastatic melanoma with germline CDKN2A mutations. J Med Genet. 2018. [Epub ahead of print]. https://doi.org/10.1136/jmedgenet-2018-105610. ID - ref17 ER - TY - JOUR AU - Han, G. C. AU - Hwang, J. AU - Wankowicz, S. A. M. AU - Zhang, Z. AU - Liu, D. AU - Cibulskis, C. PY - 2017 DA - 2017// TI - Genomic resistance patterns to second-generation androgen blockade in paired tumor biopsies of metastatic castration-resistant prostate cancer JO - JCO Precis Oncol VL - 1 ID - Han2017 ER - TY - JOUR AU - Robinson, D. AU - Allen, E. M. AU - Wu, Y. M. AU - Schultz, N. AU - Lonigro, R. J. AU - Mosquera, J. M. PY - 2015 DA - 2015// TI - Integrative clinical genomics of advanced prostate cancer JO - Cell. VL - 162 UR - https://doi.org/10.1016/j.cell.2015.06.053 DO - 10.1016/j.cell.2015.06.053 ID - Robinson2015 ER -