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Table 7 Multivariate analysis of factors predicting overall survival

From: A panel of protein kinase high expression is associated with postoperative recurrence in cholangiocarcinoma

Variable

Overall survival

HR

95% CI

p

Model A

 Primary tumor (T) (III/IV vs I/II)

2.056

1.335–3.166

0.001

 Lymph nodes metastasis (N) (Yes vs No)

1.750

1.152–2.660

0.009

 Distant metastasis (M) (Yes vs No)

1.146

0.599–2.192

0.680

 TNM Stage (III/IV vs I/II)

1.100

0.632–1.915

0.735

 EGFR (High vs Low)

1.450

1.063–1.978

0.019

Model B

 Primary tumor (T) (III/IV vs I/II)

1.991

1.286–3.084

0.002

 Lymph nodes metastasis (N) (Yes vs No)

1.642

1.067–2.526

0.024

 Distant metastasis (M) (Yes vs No)

1.106

0.577–2.119

0.761

 TNM Stage (III/IV vs I/II)

1.149

0.650–2.032

0.632

 HER4 (High vs Low)

1.198

0.875–1.641

0.259

Model C

 Primary tumor (T) (III/IV vs I/II)

1.931

1.243–3.002

0.003

 Lymph nodes metastasis (N) (Yes vs No)

1.594

1.026–2.446

0.038

 Distant metastasis (M) (Yes vs No)

1.159

0.604–2.223

0.657

 TNM Stage (III/IV vs I/II)

1.224

0.686–2.182

0.494

 EphA3 (High vs Low)

1.372

1.014–1.855

0.040

Model D

 Primary tumor (T) (III/IV vs I/II)

1.925

1.237–2.995

0.004

 Lymph nodes metastasis (N) (Yes vs No)

1.631

1.060–2.509

0.026

 Distant metastasis (M) (Yes vs No)

1.134

0.591–2.176

0.706

 TNM Stage (III/IV vs I/II)

1.178

0.665–2.089

0.574

 Protein panela (2–3 markers high vs Othersb)

1.269

0.926–1.738

0.138

Model E

 Primary tumor (T) (III/IV vs I/II)

4.006

2.033–7.893

6.0 × 10−5

 Lymph nodes metastasis (N) (Yes vs No)

2.055

1.160–3.640

0.014

 Distant metastasis (M) (Yes vs No)

0.781

0.323–1.888

0.583

 TNM Stage (III/IV vs I/II)

0.604

0.262–1.389

0.235

 Combined of protein panel and CA19–9 level (2–3 markers high and CA19–9 high vs Othersc)

1.490

0.922–2.406

0.103

  1. TNM: Size of primary tumor-node metastasis-distant metastasis, EGFR Epidermal growth factor receptor, HER Human epidermal growth factor receptor, EphA3 Erythropoietin-producing hepatocellular carcinoma receptor type-A3, Protein panela: the expression of EGFR, HER4 and EphA3, Protein panela: the expression of EGFR, HER4 and EphA, Othersb: 0–1 marker high, Othersc: three groups of patients (0–1 marker high and CA19–9 low, 0–1 marker high and CA19–9 high or 2–3 markers high and CA19–9 low)