Skip to main content

Table 2 The correlation of 12 protein kinases and post-operative recurrence of CCA patients

From: A panel of protein kinase high expression is associated with postoperative recurrence in cholangiocarcinoma

Protein kinases

Early recurrence

Late recurrence

No recurrence

 

p value

 

n = 31

n = 27

n = 132

Early vs No recurrence

Late vs No recurrence

Early vs Late recurrence

EGFR

 Low

14 (45)

19 (70)

88 (67)

0.038

0.824

0.067

 High

17 (55)

8 (30)

44 (33)

   

HER2

 Low

14 (45)

7 (26)

64 (49)

0.842

0.035

0.174

 High

17 (55)

20 (74)

68 (51)

   

HER3

 Low

22 (71)

18 (67)

86 (65)

0.674

1.000

0.781

 High

9 (29)

9 (33)

46 (35)

   

HER4

 Low

15 (48)

17 (63)

93 (71)

0.033

0.495

0.300

 High

16 (52)

10 (37)

39 (29)

   

VEGFR3

 Low

25 (81)

21 (78)

93 (71)

0.372

0.493

1.000

 High

6 (19)

6 (22)

39 (29)

   

VEGF-C

 Low

12 (39)

8 (30)

54 (41)

1.000

0.387

0.583

 High

19 (61)

19 (70)

78 (59)

   

EphA3

 Low

12 (39)

15 (56)

86 (65)

0.008

0.384

0.292

 High

19 (61)

12 (44)

46 (35)

   

EphrinA1

 Low

16 (52)

14 (52)

61 (46)

0.690

0.674

1.000

 High

15 (48)

13 (48)

71 (54)

   

p-Akt1

 Low

9 (29)

5 (19)

55 (42)

0.225

0.029

0.378

 High

22 (71)

22 (81)

77 (58)

   

Akt1

 Low

16 (52)

14 (52)

66 (50)

1.000

1.000

1.000

 High

15 (48)

13 (48)

66 (50)

   

Cytoplasmic beta-catenin

 Negative

27 (87)

22 (82)

108 (82)

0.603

1.000

0.720

 Positive

4 (13)

5 (18)

24 (18)

   

Membranous beta-catenin

 Negative

28 (90)

25 (93)

121 (92)

0.731

1.000

1.000

 Positive

3 (10)

2 (7)

11 (8)

   

Nuclear beta-catenin

 Negative

31 (100)

27 (100)

129 (98)

1.000

1.000

NA

 Positive

0 (0)

0 (0)

3 (2)

   

Wnt5a

 Low

16 (52)

9 (33)

68 (51)

1.000

0.095

0.192

 High

15 (48)

18 (67)

64 (49)

   
  1. EGFR Epidermal growth factor receptor, HER Human epidermal growth factor receptor, VEGFR3 Vascular endothelial growth factor receptor 3, VEGF-C Vascular endothelial growth factor-C, EphA3 Erythropoietin-producing hepatocellular carcinoma receptor type-A3, p-Akt1: Phosphor-serine/threonine kinase 1, Akt1 Serine/threonine kinase 1, Wnt5a Protein Wnt5a, NA Not applicable