GR, Sgk1, and NDRG1 in esophageal squamous cell carcinoma: their correlation with therapeutic outcome of neoadjuvant chemotherapy

Table 5 Pre-NAC status of GR, Sgk1, NDRG1 and its correlation with clinicopathological variables of the cases

Variable		n	pre-NAC GR expression		P	pre-NAC Sgk1 expression		P	pre-NAC NDRG1 expression		P
			High	Low		High	Low		High	Low
Age	≧65y.o	26	15	11		11	15		12	14
Age	< 65y.o	16	8	8	p = 0.627	8	8	p = 0.627	6	10	p = 0.581
Gender	Male	35	18	17		15	20		13	22
Gender	Female	7	5	2	p = 0.332	4	3	p = 0.489	5	2	p = 0.094
pT^a	pT1a~pT1b	11	5	6		3	8		3	8
pT^a	pT2~pT4b	31	18	13	p = 0.470	16	15	p = 0.156	15	16	p = 0.216
pN^a	pN0	15	6	9		5	10		9	15
pN^a	pN1~N3	27	17	10	p = 0.152	14	13	p = 0.246	12	15	p = 0.780
cM^a	cM0	40	22	18		17	23		17	23
cM^a	cM1	2	1	1	p = 0.890	2	0	p = 0.070	1	1	p = 0.835
pStage^a	pStageI,II	17	6	11		4	13		5	12
pStage^a	pStageIII,IV	25	17	8	p = 0.037*	15	10	p = 0.020	13	12	p = 0.147
Tumor differentiation^a	well,moderate	37	20	17		16	21		17	20
	poor	4	3	1	p = 0.427	3	1	p = 0.220	1	3	p = 0.426
	Unclassifiable	1	0	1		0	1		0	1
Lymphatic invasion	Absence	13	6	7		4	9		5	8
Lymphatic invasion	Presence	29	17	12	p = 0.453	15	14	p = 0.207	13	16	p = 0.700
Vessel invasion	Absence	8	6	3		4	5		4	5
Vessel invasion	Presence	34	17	16	p = 0.418	15	18	p = 0.957	14	19	p = 0.914
RECIST grade^b	CR/PR	14	5	9		4	10		3	11
	SD/PD	25	16	9	p = 0.089	14	11	p = 0.097	15	10	p = 0.021*
	Indeterminate	3	2	1		1	2		0	3
Histopathological tumor regression grade^c	Grade0~1a	27	17	10		14	13		14	13
Histopathological tumor regression grade^c	Grade1b~ 2	15	6	9	p = 0.152	5	10	p = 0.246	4	11	p = 0.109
Total		42	23	19		19	23		18	24

* Statistical significance
^a Tumor-node-metastasis (TNM) classification based on the 8th edition of the TNM classification of malignant tumors
^b New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)
^c Histopathological features based on the Japanese Classification of Esophageal Cancer, 11th edition (Japan Esophageal Society 2015)

ISSN: 1471-2407