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Table 1 post-NAC status of GR, Sgk1, NDRG1 and its correlation with clinicopathological variables

From: GR, Sgk1, and NDRG1 in esophageal squamous cell carcinoma: their correlation with therapeutic outcome of neoadjuvant chemotherapy

Variable

 

n

post-NAC GR expression

P

post-NAC Sgk1 expression

P

post-NAC NDRG1 expression

P

   

High

Low

 

High

Low

 

High

Low

 

Age

≧65y.o

62

32

30

 

35

27

 

22

40

 

< 65y.o

36

20

16

p = 0.706

18

18

p = 0.537

16

20

p = 0.380

Gender

Male

83

43

40

 

48

35

 

32

41

 

Female

15

9

6

p = 0.559

5

10

p = 0.080

6

9

p = 0.915

pTa

pT1a~pT1b

28

12

16

 

9

19

 

1

27

 

pT2~pT4b

70

40

30

p = 0.201

44

26

p = 0.006*

37

33

p < 0.001*

pNa

pN0

29

14

15

 

7

22

 

9

20

 

pN1~N3

69

38

31

p = 0.539

46

23

p < 0.001*

29

40

p = 0.308

cMa

cM0

94

50

44

 

49

45

 

36

58

 

cM1

4

2

2

p = 0.900

4

0

p = 0.060

2

2

p = 0.638

pStagea

pStageI,II

40

20

20

 

11

29

 

9

31

 

pStageIII,IV

58

32

26

p = 0.614

42

16

p < 0.001*

29

29

p = 0.006*

Tumor differentiationa

well,moderate

84

47

37

 

44

40

 

33

51

 

poor

10

4

6

p = 0.339

8

2

p = 0.097

5

5

p = 0.517

Unclassifiable

4

1

3

 

1

3

 

0

4

 

Lymphatic invasion

Absence

29

14

15

 

9

20

 

9

20

 

Presence

69

38

31

p = 0.538

44

25

p = 0.003*

29

40

p = 0.308

Vessel invasion

Absence

18

5

13

 

6

12

 

3

15

 

Presence

80

47

33

p = 0.016*

47

33

p = 0.051

35

45

p = 0.033*

RECIST gradeb

CR/PR

28

12

16

 

10

18

 

8

20

 

SD/PD

57

34

23

p = 0.144

38

19

p = 0.007*

28

29

p = 0.072

 

Indeterminate

13

6

7

 

5

8

 

2

11

 

Histopathological tumor regression gradec

Grade0~1a

63

37

26

 

39

24

 

27

36

 

Grade1b~ 2

35

15

20

p = 0.131

14

21

p = 0.037*

11

24

p = 0.267

Total

 

98

52

46

 

53

45

 

38

60

 
  1. * Statistical significance
  2. a Tumor-node-metastasis (TNM) classification based on the 8th edition of the TNM classification of malignant tumors
  3. b New response evaluation criteria in solid tumors: revised RECIST guideline (version 1.1)
  4. c Histopathological features based on the Japanese Classification of Esophageal Cancer, 11th edition (Japan Esophageal Society 2015)