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Table 1 Clinicopathologic characteristics in patients

From: Neoadjuvant chemotherapy-induced decrease of prognostic nutrition index predicts poor prognosis in patients with breast cancer

Variables

 

Total

low ΔPNI

high ΔPNI

 
  

n = 191 (%)

n = 91 (%)

n = 100 (%)

p value

Age(mean ± SD)

 

51.2 ± 10.4

50.9 ± 9.26

51.5 ± 11.3

0.68

Sex(Male/Female)

 

0/191

0/91

0/100

 

Pre-NAC clinical stage

I

1 (0.5%)

1 (1.1%)

0 (0%)

0.67

 

II

118 (61.8%)

52 (57.2%)

66 (66.0%)

 
 

III

72 (37.7%)

38 (41.7%)

34 (34.0%)

 
 

IV

0 (0%)

0 (0%)

0 (0%)

 

Histological type

IDC

171 (89.5%)

81 (89.0%)

90 (90.0%)

0.89

 

ILC

12 (6.3%)

7 (7.7%)

5 (5.0%)

 
 

Special type

8 (4.2%)

3 (3.3%)

5 (5.0%)

 

HG

1

54 (28.3%)

18 (19.9%)

36 (36.0%)

0.15

 

2

89 (46.6%)

47 (51.6%)

42 (42.0%)

 
 

3

23 (12.0%)

14 (15.3%)

9 (9.0%)

 
 

Unknown

25 (13.1%)

12 (13.2%)

13 (13.0%)

 

Subtype

Lunimal

107 (56.0%)

51 (56.0%)

56 (56.0%)

0.79

 

Luninal HER2

37 (19.4%)

19 (20.9%)

18 (18.0%)

 
 

HER2 enriched

24 (12.6%)

12 (13.2%)

12 (12.0%)

 
 

TNBC

23 (12.0%)

9 (9.9%)

14 (14.0%)

 

Regimens of NAC

AC

11 (5.8%)

10 (11.0%)

1 (1.0%)

0.02

 

AC → PTX and/or HER

91 (47.6%)

52 (57.2%)

39 (39.0%)

 
 

AC → DOC and/or HER

89 (46.6%)

29 (31.8%)

60 (60.0%)

 

Operation procedures

Bt,Ax

128 (67.1%)

59 (64.8%)

69 (69.0%)

0.65

 

Bp,Ax

63 (32.9%)

32 (35.2%)

31 (31.0%)

 

Pathological response to NAC

non-pCR

154 (80.6%)

78 (85.7%)

76 (76.0%)

0.10

 

pCR

37 (19.4%)

13 (14.3%)

24 (24.0%)

 

Pre-NAC PNI

 

52.6 ± 3.8

50.9 ± 3.7

54.1 ± 3.6

< 0.01

Post-NAC PNI

 

46.5 ± 4.5

48.8 ± 3.9

44.5 ± 4.0

< 0.01

Recurrence

 

38 (19.9%)

13 (14.3%)

25 (25.0%)

0.06

  1. NAC Neoadjuvant chemotherapy, HG Histological grade, IDC Invasive ductal carcinoma, ILC Invasive lobular carcinoma, AC Antracycline, PTX paclitaxel, DOC docetaxel, HER Trastuzumab, Bt Mastectomy, Bp Partial resection of breast, Ax Axillary dissection, NAC neoadjuvant chemotherapy, PNI prognostic nutritional index