|
Probe ID (HG-U133)
|
miRNA
|
Drug sensitivity
|
Annotation grade
|
|---|
|
232504_at
|
miR-146a
|
↓ Cyc, ↑ Vin
|
A
|
|
238225_at
|
miR-146a
|
↓ Cyc, ↑ Vin
|
B
|
|
229437_at
|
miR-155
|
↓ Rtx, ↑ Dox, ↑Vin
|
A
|
|
220990_s_at
|
miR-21
|
↑ Vin
|
A
|
|
229417_at
|
miR-21
|
↑ Vin
|
E
|
|
235317_at
|
miR-23a~miR-27a~miR-24-2
|
↑ Dox, ↑ Vin
|
B
|
|
1555847_a_at
|
miR-23a~miR-27a~miR-24-2
|
↑ Dox, ↑ Vin
|
A
|
|
235571_at
|
miR-34a
|
↑ Dox, ↑ Vin
|
A
|
|
1557342_a_at
|
let-7b
|
↑ Vin
|
A
|
|
241464_s_at
|
let-7b
|
↑ Vin
|
B
|
|
227488_at
|
miR-503
|
↓ Rtx
|
B
|
- Differentially expressed miRNAs detected by HG-U133 Plus 2.0 probes were selected as candidate miRNAs. The list consisted of 11 probe sets detecting 9 miRNAs. The annotation grade was assessed by NetAffx (Affymetrix) a transcript assignment pipeline creating a relationship between GeneChip probe sets and current transcript record. The transcript assignment grades fall into five categories A-E that describe the quality of the direct evidence. Grade A is a matching probe set having nine or more probes matching transcript mRNA. Grade B transcript assignments have partial overlap between transcripts and target sequence. Grade E is given when no transcript is found. Abbreviations: ↑ and ↓ defines up- and downregulation, respectively, in drug sensitive cell lines. Cyc, cyclophosphamide; Dox, doxorubicin; Rtx, rituximab; Vin, vincristine
