Table 3 Top five pathways related to the best target candidates of miRNAs differentially expressed between normal tissues and BRCA1/2-germline mutation carriers and BRCAX cases
Pathway | Genes (targets) | FDR-correctedP value |
|---|---|---|
ErbB signaling pathway | AKT2, AKT3, PRKCB, PLCG1, STAT5B, JUN, CDKN1A, CDKN1B, EGFR, NRAS, MAP 2 K4, MAP 2 K1, ABL1, PIK3CB, NRG1, PIK3CA, SRC, CBL, ERBB3, ERBB4, MAPK1, KRAS | 2,89E-15 |
FoxO signaling pathway | AKT2, AKT3, CREBBP, ATM, CDKN1A, CDKN1B, IKBKB, SGK1, EGFR, NRAS, STAT3, STK11, CCND2, CCND1, EP300, MAP 2 K1, FOXO3, FOXO1, SMAD2, SMAD4, SMAD3, BCL6, MDM2, PTEN, PIK3CB, TGFBR2, PIK3CA, MAPK1, KRAS | 2,89E-15 |
MicroRNAs in cancer | TP63, PRKCB, TP53, PLCG1, CREBBP, ATM, EZH2, CDKN1A, CDKN1B, BRCA1, IKBKB, RHOA, EGFR, NRAS, CDKN2A, STAT3, TNC, CCND2, CCND1, PIM1, EP300, MAP 2 K1, FOXP1, CCNE1, NOTCH2, NOTCH1, SOCS1, ABL1, HMGA2, CDK6, MDM2, BCL2, MDM4, FGFR3, PTEN, CASP3, PIK3CA, MET, ERBB3, MAPK1, APC, KRAS | 2,89E-15 |
PI3K-Akt signaling pathway | PPP2R1A, AKT2, MYB, AKT3, KDR, TP53, CDKN1A, CDKN1B, BRCA1, IKBKB, RAC1, JAK1, KIT, SGK1, EGFR, NRAS, TNC, STK11, CCND3, CCND2, CCND1, MAP 2 K1, TSC1, CCNE1, CSF1R, FOXO3, CDK6, MDM2, BCL2, FGFR3, FGFR2, FGFR1, PTEN, PIK3CB, ITGAV, PIK3CA, MET, MAPK1, KRAS | 2,89E-15 |
Breast cancer | RB1, AKT2, AKT3, TP53, JUN, CDKN1A, BRCA1, NCOA1, KIT, EGFR, NRAS, CTNNB1, CCND1, MAP 2 K1, NOTCH2, NOTCH1, ESR1, CDK6, FGFR1, PTEN, PIK3CB, AXIN2, PIK3CA, MAPK1, TCF7L2, APC, KRAS | 2,89E-15 |