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Table 2 ROC curve analysis for miRNAs as potential biomarkers in hereditary breast cancer

From: miRNA expression profiling of hereditary breast tumors from BRCA1- and BRCA2-germline mutation carriers in Brazil

 Normal vs. BRCA1Normal vs. BRCA2Normal vs. BRCAX
microRNASenSpeAUCCutoffSenSpeAUCCutoffSenSpeAUCCutoff
hsa-miR-28-5p87%88%0.914.0778%88%0.844.49100%100%1.005.37
hsa-miR-361-3p93%75%0.882.4971%100%0.893.35100%100%1.003.38
hsa-miR-93-5p87%100%0.934.9486%100%0.904.97100%100%1.005.91
hsa-miR-32-5p93%75%0.882.6493%100%0.933.14100%100%1.004.24
hsa-miR-191-5p80%88%0.855.6186%100%0.946.2093%100%0.996.11
hsa-miR-27b-3p87%75%0.883.4871%88%0.824.02100%100%1.004.74
hsa-miR-21-5p60%100%0.817.2086%100%0.897.11100%100%1.007.88
hsa-miR-16-5p73%88%0.876.0778%88%0.855.92100%100%1.006.54
hsa-miR-340-5p67%88%0.833.5578%88%0.873.5593%100%0.994.16
hsa-miR-194-5p100%63%0.811.7178%88%0.862.7893%88%0.952.69
hsa-miR-142-3p80%100%0.936.1071%100%0.827.3993%100%0.986.92
hsa-miR-22-3p80%88%0.913.5078%100%0.844.13100%100%1.004.10
hsa-miR-15b-5p87%75%0.884.5071%100%0.846.47100%100%1.006.05
hsa-miR-141-3p80%100%0.925.3678%100%0.895.9993%100%0.935.77
hsa-miR-106b-5p87%88%0.923.8093%75%0.883.21100%100%1.004.49
hsa-miR-425-5p93%75%0.851.6686%88%0.952.2193%88%0.962.43
hsa-miR-4454 + hsa-miR-797573%100%0.8813.7271%88%0.8213.33100%100%1.0013.88
hsa-miR-196a-5p73%100%0.874.2486%100%0.964.29100%88%0.994.07
hsa-miR-324-5p80%88%0.883.0786%88%0.843.2986%100%0.953.62
hsa-miR-20a-5p + hsa-miR-20b-5p67%88%0.805.0671%100%0.835.79100%88%0.985.01
hsa-let-7d-5p73%75%0.835.9071%88%0.816.36100%100%1.006.64
hsa-miR-19a-3p67%100%0.813.2171%88%0.803.0293%100%0.993.43
hsa-miR-146a-5p100%75%0.893.7871%88%0.854.4286%88%0.954.43
hsa-miR-200c-3p87%75%0.887.1171%100%0.877.9578%100%0.867.78
hsa-miR-106a-5p + hsa-miR-17-5p60%100%0.814.7964%100%0.804.8478%88%0.924.47
  1. Sen, sensitivity; spe, specificity; AUC, area under the curve.