Stereotactic body radiotherapy (SBRT) in patients with lung metastases - prognostic factors and long-term survival using patient self-reported outcome (PRO)

Table 3 P-values of univariate and multivariate analyses for OS, DP, and LC. Multivariate analysis was performed with the significant items of univariate analysis

	OS (n = 219)		DP (n = 219)		LC (n = 316)
	UVA	MVA	UVA	MVA	UVA	MVA
Age at RT°	0.667	–	0.630	–	0.003*	0.320
Gender	0.401	–	0.092	–	0.220	–
KPS (< 90 vs. ≥90%)	< 0.001*	< 0.001*	< 0.001*	< 0.001*	0.844	–
Primary tumor type (NSCLC vs CRC vs. Melanoma vs. Breast)	0.985	–	0.954	–	0.437	–
GTV°	< 0.002*	0.439	0.035*	0.919	0.762	–
GTV (< 8 vs ≥8 ml)	< 0.001*	–	0.005*	–	0.844	–
PTV°	0.003*	0.904	0.046*	0.599	0.211	–
PTV (< 35 vs ≥35 ml)	< 0.001*	–	0.017*	–	0.842	–
Planning PET-CT	0.264	–	0.765	–	0.133	–
Number of pulmonary METs (≤3 vs. > 3)	< 0.001*	0.014*	0.078	–	< 0.001*	< 0.001*
Absence extra thoracic MET	< 0.001*	0.020*	< 0.001*	< 0.001*	0.859	–
Controlled primary tumor	< 0.001*	< 0.001*	0.001*	0.003*	0.632	–
CHT between MET diagnosis and SBRT	0.047*	0.176	0.468	–	0.097	–
BED_10iso°	0.001*	0.289	0.413	–	0.429	–
BED_10PTVmean°	0.007*	0.468	0.439	–	0.955	–
Time from primary diagnosis to MET diagnosis°	0.090	–	0.985	–	0.882	–
Time from primary diagnosis to MET diagnosis (< 12 vs. ≥12 months)	0.884	–	0.291	–	0.336	–

UVA Univariate analysis, MVA Multivariate analysis, OS Overall survival, DP Distant progression, LC Local control, KPS Karnofsky Performance Score, RT Radiotherapy, CHT Chemotherapy, MET Metastasis, PTV Planning target volume, GTV Gross tumor volume, NSCLC non-small cell lung cancer, CRC colorectal carcinoma, * significant p-value, ° continuous variable

ISSN: 1471-2407