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Table 3 Multivariate Analyses of Prognostic Factors of tumor-related death among 568 patients using the ENETS, 8th AJCC, 7th AJCC and m7th AJCC staging systems including four tumor stages for pNECs

From: Validation and modification of staging Systems for Poorly Differentiated Pancreatic Neuroendocrine Carcinoma

CharacteristicENETS8th AJCC7th AJCCm7th AJCC
HR (95% CI)PHR (95% CI)PHR (95% CI) HR (95% CI)P
Age, years
  < 601 1 1 1 
  ≥ 601.63 (1.33–2.00)< 0.0011.64 (1.34–2.01)< 0.0011.66 (1.35–2.03)< 0.0011.66 (1.35–2.03)< 0.001
Sex
 Female1 1 1 1 
 Male1.16 (0.95–1.41)0.151.16 (0.95–1.41)0.151.14 (0.94–1.40)0.181.14 (0.94–1.40)0.18
Race
 Black1 1 1 1 
 White0.65 (0.48–0.88)0.010.66 (0.49–0.90)0.010.67 (0.50–0.91)0.010.67 (0.50–0.91)0.01
 Other0.65 (0.43–0.99)0.040.68 (0.45–1.04)0.070.68 (0.45–1.03)0.070.68 (0.45–1.03)0.07
Location
 Body and tail1 1 1 1 
 Head1.63 (1.29–2.08)< 0.0011.61 (1.27–2.05)< 0.0011.60 (1.26–2.03)< 0.0011.60 (1.26–2.04)< 0.001
 Others1.67 (1.29–2.15)< 0.0011.68 (1.30–2.17)< 0.0011.67 (1.21–2.15)< 0.0011.67 (1.29–2.16)< 0.001
Stage
 I1 1 1 1 
 II3.27 (0.77–14.02)0.110.74 (0.41–1.34)0.321.08 (0.60–1.94)0.801.23 (0.73–2.06)0.44
 III2.23 (0.54–9.18)0.271.81 (0.97–3.38)0.062.06 (0.94–4.52)0.072.20 (1.06–4.56)0.03
 IV9.59 (2.38–38.71)0.0024.14 (2.52–6.79)< 0.0014.62 (2.73–7.83)< 0.0014.95 (3.20–7.65)< 0.001
  1. Abbreviations: AJCC American Joint Committee on Cancer; ENETS European Neuroendocrine Tumor Society; m7th AJCC modified 7th AJCC; pNECs poorly differentiated pancreatic neuroendocrine carcinomas; HR hazard ratio; CI confidence interval