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Table 4 Associations between lymphocyte subsets and clinicopathological parameters

From: Clinical significance of peripheral blood and tumor tissue lymphocyte subsets in cervical cancer patients

 

Age (years)

FIGO stage

Histology

Tumor size

Stromal invasion

LN metastasis

LVSI

≤47

> 47

P

I

II

P

SCC

ADC

P

≤4 cm

> 4 cm

P

≤1/2

> 1/2

P

No

Yes

P

No

Yes

P

Blood (n = 43)

 Gran %CD45

3.47 ± 6.06

2.45 ± 4.08

0.537

2.17 ± 3.92

4.06 ± 6.49

0.266

2.68 ± 4.95

5.82 ± 7.50

0.216

2.43 ± 3.39

3.83 ± 7.03

0.431

2.34 ± 4.88

3.35 ± 5.51

0.57

1.76 ± 2.76

4.84 ± 7.25

0.101

2.01 ± 3.94

4.13 ± 6.33

0.198

 T %MNC

57.57 ± 12.26

57.19 ± 13.85

0.925

56.69 ± 12.69

58.25 ± 13.19

0.694

57.70 ± 13.39

55.22 ± 7.18

0.688

53.35 ± 10.22

62.55 ± 14.08

0.017

56.56 ± 14.17

57.78 ± 12.38

0.777

56.88 ± 13.82

58.16 ± 11.55

0.751

56.44 ± 13.59

58.44 ± 12.14

0.614

 CD4%T

57.49 ± 9.65

53.42 ± 15.93

0.304

57.17 ± 11.74

54.19 ± 13.76

0.447

55.41 ± 13.00

59.43 ± 9.07

0.552

58.25 ± 10.16

52.67 ± 14.94

0.153

59.35 ± 10.65

54.24 ± 13.30

0.229

58.17 ± 10.08

52.47 ± 15.23

0.147

56.98 ± 10.72

54.54 ± 14.57

0.534

 CD8%T

31.18 ± 7.98

31.94 ± 13.81

0.821

29.73 ± 9.48

33.54 ± 11.79

0.248

31.95 ± 10.92

27.10 ± 7.15

0.392

29.64 ± 8.32

33.86 ± 12.89

0.201

30.75 ± 9.19

31.83 ± 11.37

0.764

29.36 ± 7.71

34.48 ± 13.44

0.121

30.70 ± 8.18

32.34 ± 12.92

0.619

 CD4:CD8

2.06 ± 0.92

2.03 ± 1.04

0.936

2.22 ± 1.05

1.85 ± 0.83

0.204

2.02 ± 0.97

2.35 ± 0.87

0.513

2.20 ± 0.94

1.85 ± 0.97

0.242

2.22 ± 1.09

1.97 ± 0.91

0.44

2.19 ± 0.89

1.85 ± 1.04

0.254

2.07 ± 0.92

2.02 ± 1.02

0.873

 rdT %T

7.2 ± 4.69

7.45 ± 4.32

0.91

6.10 ± 3.70

8.90 ± 5.06

0.16

7.42 ± 4.72

6.60 ± 2.75

0.775

7.23 ± 4.35

7.46 ± 4.99

0.915

5.07 ± 3.49

8.42 ± 4.55

0.105

7.43 ± 4.07

7.00 ± 5.71

0.848

6.67 ± 4.33

8.57 ± 4.73

0.369

 B %MNC

6.05 ± 3.07

6.03 ± 3.25

0.983

6.13 ± 3.50

5.96 ± 2.71

0.86

5.99 ± 3.14

6.44 ± 3.18

0.766

6.30 ± 3.24

5.71 ± 2.99

0.546

6.40 ± 3.10

5.90 ± 3.16

0.646

6.61 ± 3.48

5.22 ± 2.32

0.157

7.03 ± 3.42

5.06 ± 2.47

0.039

 pDC % MNC

0.26 ± 0.13

0.23 ± 0.11

0.415

0.26 ± 0.14

0.24 ± 0.11

0.583

0.25 ± 0.13

0.24 ± 0.05

0.904

0.23 ± 0.11

0.27 ± 0.14

0.212

0.25 ± 0.16

0.24 ± 0.11

0.805

0.24 ± 0.12

0.26 ± 0.14

0.526

0.22 ± 0.12

0.28 ± 0.13

0.133

 CD11c + % pDC

7.71 ± 6.14

7.49 ± 2.98

0.909

8.09 ± 6.31

7.01 ± 2.76

0.553

7.40 ± 4.94

9.13 ± 6.24

0.531

6.74 ± 3.28

8.91 ± 6.80

0.237

9.31 ± 8.32

6.96 ± 2.98

0.429

7.83 ± 3.63

7.27 ± 6.95

0.765

9.24 ± 6.28

5.78 ± 2.05

0.044

 Baso % MNC

1.09 ± 0.80

0.83 ± 0.54

0.248

1.07 ± 073

0.89 ± 0.69

0.41

0.92 ± 0.65

1.60 ± 1.00

0.065

1.02 ± 0.65

0.93 ± 0.78

0.686

1.08 ± 0.59

0.94 ± 0.76

0.534

1.00 ± 0.70

0.95 ± 0.73

0.808

1.03 ± 0.58

0.93 ± 0.83

0.637

 BDCA1+ mDC % MNC

0.39 ± 0.18

0.35 ± 0.19

0.547

0.34 ± 0.23

0.42 ± 0.10

0.21

0.36 ± 0.18

0.57 ± 0.12

0.062

0.38 ± 0.14

0.37 ± 0.24

0.826

0.29 ± 0.20

0.41 ± 0.17

0.087

0.37 ± 0.22

0.39 ± 0.12

0.717

0.32 ± 0.21

0.44 ± 0.14

0.074

 BDCA3+ mDC % MNC

0.02 ± 0.04

0.02 ± 0.04

0.875

0.02 ± 0.04

0.01 ± 0.03

0.237

0.01 ± 0.04

0.05 ± 0.07

0.203

0.03 ± 0.05

0

0.02

0.03 ± 0.05

0.01 ± 0.04

0.477

0.02 ± 0.04

0.02 ± 0.04

0.871

0.02 ± 0.04

0.01 ± 0.04

0.754

 Mono %MNC

17.19 ± 9.54

13.30 ± 8.56

0.177

15.88 ± 9.83

15.19 ± 8.75

0.81

15.48 ± 9.60

16.14 ± 6.60

0.884

16.14 ± 7.88

14.83 ± 10.91

0.651

15.80 ± 11.75

15.46 ± 8.16

0.925

13.82 ± 8.77

17.97 ± 9.59

0.149

15.61 ± 10.16

15.50 ± 8.43

0.97

 CD14+ Mo % MNC

16.31 ± 7.38

12.18 ± 5.76

0.101

13.64 ± 7.69

15.91 ± 5.99

0.371

14.53 ± 7.17

15.38 ± 6.35

0.824

14.37 ± 6.06

15.02 ± 8.41

0.802

13.21 ± 10.31

15.19 ± 5.38

0.597

13.01 ± 6.89

17.33 ± 6.53

0.09

13.81 ± 8.44

15.56 ± 4.97

0.476

 CD16+ Mo % MNC

2.68 ± 1.65

3.65 ± 2.77

0.274

2.82 ± 2.47

3.39 ± 1.79

0.473

3.14 ± 2.32

2.60 ± 0.89

0.652

3.57 ± 2.49

2.35 ± 1.44

0.09

2.44 ± 2.23

3.32 ± 2.17

0.332

2.78 ± 1.95

3.57 ± 2.54

0.329

2.54 ± 1.80

3.68 ± 2.47

0.142

 CD16+ %Mono

14.68 ± 6.43

21.81 ± 8.06

0.009

17.03 ± 8.41

18.29 ± 7.33

0.661

17.75 ± 7.85

16.38 ± 8.98

0.749

19.47 ± 7.83

14.81 ± 7.32

0.1

16.34 ± 7.16

18.06 ± 8.22

0.567

17.77 ± 7.2

17.27 ± 8.72

0.865

16.65 ± 8.29

18.63 ± 7.48

0.485

 NK %MNC

14.08 ± 7.89

19.08 ± 10.70

0.089

16.16 ± 10.07

16.05 ± 8.66

0.97

15.92 ± 9.79

17.88 ± 2.54

0.696

19.52 ± 9.59

11.56 ± 6.89

0.005

16.06 ± 13.23

16.13 ± 7.26

0.983

17.82 ± 11.08

13.58 ± 5.30

0.106

15.93 ± 10.99

16.30 ± 7.40

0.9

 CD56hi NK % MNC

0.33 ± 0.15

0.33 ± 0.15

0.935

0.32 ± 0.16

0.34 ± 0.13

0.804

0.33 ± 0.16

0.35 ± 0.06

0.559

0.31 ± 0.15

0.36 ± 0.14

0.3

0.34 ± 0.19

0.32 ± 0.13

0.704

0.35 ± 0.17

0.29 ± 0.11

0.241

0.34 ± 0.18

0.31 ± 0.11

0.596

 CD56lo NK % MNC

15.29 ± 8.37

20.13 ± 10.91

0.166

17.23 ± 10.95

17.29 ± 8.01

0.986

17.22 ± 10.28

17.53 ± 2.59

0.954

20.55 ± 9.72

12.45 ± 7.43

0.017

18.57 ± 15.14

16.75 ± 6.79

0.736

18.58 ± 11.44

15.06 ± 5.16

0.244

16.66 ± 11.42

17.94 ± 7.42

0.714

 CD56hi %NK

2.73 ± 1.94

2.28 ± 2.26

0.553

2.83 ± 2.56

2.18 ± 1.13

0.345

2.63 ± 2.18

1.98 ± 0.61

0.563

1.72 ± 1.06

3.75 ± 2.57

0.017

2.97 ± 2.53

2.38 ± 1.88

0.476

2.77 ± 2.43

2.18 ± 1.23

0.441

3.06 ± 2.56

1.96 ± 1.09

0.121

 MDSC % CD33hi

1.45 ± 2.45

2.44 ± 4.33

0.416

1.49 ± 2.70

2.31 ± 4.04

0.501

2.00 ± 3.52

0.83 ± 0.93

0.518

1.46 ± 2.43

2.42 ± 4.36

0.434

0.70 ± 0.57

2.30 ± 3.83

0.226

0.75 ± 0.68

3.68 ± 4.94

0.065

0.67 ± 0.63

3.19 ± 4.50

0.05

 DR- %14 + APC

0.44 ± 1.04

0.62 ± 2.13

0.761

0.87 ± 2.01

0.06 ± 0.09

0.107

0.58 ± 1.65

0.08 ± 0.15

0.554

0.08 ± 0.15

1.15 ± 2.33

0.125

0.29 ± 0.79

0.60 ± 1.77

0.617

0.65 ± 1.89

0.28 ± 0.69

0.525

0.66 ± 1.90

0.35 ± 1.05

0.578

 DR- %16 + APC

1.13 ± 1.94

0.53 ± 0.88

0.309

1.38 ± 1.95

0.24 ± 0.61

0.029

0.99 ± 1.69

0.13 ± 0.13

0.319

0.49 ± 0.75

1.46 ± 2.28

0.16

0.60 ± 0.81

1.00 ± 1.83

0.539

1.08 ± 1.90

0.56 ± 0.92

0.381

0.94 ± 1.28

0.82 ± 1.95

0.835

Tissue (n = 35)

 Gran %CD45

11.18 ± 15.73

9.1 ± 7.95

0.643

8.48 ± 10.29

11.93 ± 14.63

0.428

10.71 ± 12.97

5.40 ± 8.50

0.495

8.54 ± 14.45

12.28 ± 10.19

0.391

10.46 ± 16.45

10.18 ± 11.44

0.956

11.38 ± 13.34

8.56 ± 9.84

0.526

13.16 ± 15.69

6.79 ± 6.58

0.12

 T %MNC

63.97 ± 21.84

75.21 ± 8.67

0.05

73.72 ± 11.79

64.76 ± 21.53

0.139

68.14 ± 18.30

79.50 ± 6.17

0.298

69.46 ± 20.43

68.70 ± 14.82

0.903

67.14 ± 23.32

69.79 ± 16.01

0.707

71.27 ± 17.29

65.87 ± 18.78

0.388

71.22 ± 15.49

66.61 ± 20.51

0.455

 CD4%T

43.98 ± 16.01

47.32 ± 12.53

0.504

48.31 ± 14.14

42.86 ± 14.57

0.27

45.13 ± 14.79

49.57 ± 10.77

0.617

49.15 ± 13.38

41.19 ± 14.82

0.105

50.23 ± 15.25

43.87 ± 14.05

0.26

50.45 ± 11.76

38.10 ± 15.25

0.011

39.88 ± 13.92

52.19 ± 12.29

0.01

 CD8%T

47.34 ± 15.92

43.21 ± 11.74

0.397

42.68 ± 12.47

48.06 ± 15.41

0.266

45.68 ± 14.36

42.93 ± 13.46

0.752

41.10 ± 13.04

50.61 ± 13.98

0.045

38.96 ± 12.74

47.70 ± 14.10

0.111

40.08 ± 11.89

53.50 ± 13.69

0.004

50.61 ± 13.71

39.33 ± 12.36

0.016

 CD4:CD8

1.17 ± 0.82

1.24 ± 0.66

0.759

1.32 ± 0.71

1.09 ± 0.77

0.374

1.19 ± 0.75

1.31 ± 0.73

0.802

1.41 ± 0.81

0.96 ± 0.58

0.07

1.55 ± 0.96

1.08 ± 0.62

0.099

1.44 ± 0.73

0.85 ± 0.62

0.019

0.92 ± 0.55

1.54 ± 0.80

0.01

 rdT %T

3.43 ± 1.84

1.53 ± 1.05

0.014

2.55 ± 1.73

2.60 ± 1.94

0.952

2.42 ± 1.54

3.95 ± 4.03

0.687

2.57 ± 1.94

2.59 ± 1.61

0.985

3.44 ± 2.07

2.11 ± 1.49

0.112

2.61 ± 1.93

2.43 ± 1.21

0.857

2.75 ± 1.98

2.04 ± 0.94

0.454

 B %MNC

4.42 ± 3.37

5.78 ± 3.41

0.252

4.67 ± 3.50

5.41 ± 3.38

0.534

5.10 ± 3.32

4.70 ± 5.07

0.851

4.32 ± 2.90

6.00 ± 3.85

0.157

4.04 ± 2.67

5.38 ± 3.59

0.339

4.68 ± 3.00

5.68 ± 4.04

0.41

4.54 ± 2.11

5.65 ± 4.45

0.372

 pDC % MNC

0.66 ± 0.68

0.64 ± 0.92

0.94

0.71 ± 0.85

0.59 ± 0.74

0.65

0.65 ± 0.78

0.67 ± 0.98

0.967

0.36 ± 0.32

0.99 ± 1.02

0.028

0.49 ± 0.49

0.70 ± 0.87

0.487

0.67 ± 0.95

0.61 ± 0.46

0.837

0.62 ± 0.69

0.69 ± 0.90

0.792

 CD11c + % pDC

5.39 ± 5.60

6.21 ± 3.66

0.647

5.76 ± 3.53

5.81 ± 5.84

0.979

5.64 ± 4.35

7.70 ± 10.89

0.834

5.57 ± 5.03

6.13 ± 4.31

0.764

4.21 ± 4.06

6.38 ± 4.87

0.274

4.77 ± 3.91

7.70 ± 5.64

0.112

4.97 ± 3.57

6.93 ± 5.92

0.321

 Baso % MNC

0.11 ± 0.16

0.06 ± 0.16

0.328

0.12 ± 0.20

0.05 ± 0.10

0.192

0.08 ± 0.17

0.13 ± 0.12

0.6

0.06 ± 0.13

0.11 ± 0.19

0.375

0.11 ± 0.18

0.08 ± 0.16

0.591

0.10 ± 0.19

0.07 ± 0.11

0.675

0.08 ± 0.16

0.09 ± 0.17

0.953

 BDCA1+ mDC % MNC

0.11 ± 0.07

0.11 ± 0.18

0.882

0.11 ± 0.08

0.11 ± 0.17

0.926

0.11 ± 0.14

0.10 ± 0.00

0.913

0.11 ± 0.18

0.11 ± 0.06

0.904

0.10 ± 0.08

0.11 ± 0.15

0.82

0.15 ± 0.17

0.06 ± 0.05

0.074

0.07 ± 0.07

0.17 ± 0.18

0.057

 BDCA3+ mDC % MNC

0.03 ± 0.08

0

0.136

0.01 ± 0.03

0.03 ± 0.08

0.451

0.02 ± 0.06

0

0.682

0.03 ± 0.08

0.01 ± 0.03

0.392

0.04 ± 0.11

0.01 ± 0.03

0.464

0.03 ± 0.08

0.01 ± 0.03

0.392

0.01 ± 0.02

0.03 ± 0.09

0.317

 Mono %MNC

10.22 ± 9.84

6.28 ± 5.50

0.164

9.48 ± 9.17

7.41 ± 7.47

0.468

8.78 ± 8.52

4.50 ± 4.04

0.4

5.48 ± 4.78

11.90 ± 10.22

0.032

8.90 ± 11.80

8.25 ± 6.98

0.843

7.42 ± 8.05

9.91 ± 8.71

0.393

10.33 ± 10.36

6.15 ± 4.09

0.119

 CD14+ Mo % MNC

2.62 ± 2.76

1.76 ± 1.77

0.329

2.43 ± 2.72

1.96 ± 1.92

0.593

2.28 ± 2.39

1.15 ± 1.20

0.519

1.34 ± 1.31

3.61 ± 2.98

0.034

2.06 ± 2.86

2.26 ± 2.18

0.845

2.35 ± 2.38

1.93 ± 2.36

0.656

2.79 ± 2.78

1.37 ± 1.18

0.071

 CD16+ Mo % MNC

6.19 ± 7.02

5.09 ± 4.16

0.615

6.15 ± 5.32

5.12 ± 6.33

0.638

5.78 ± 5.88

4.00 ± 4.38

0.681

3.49 ± 2.98

9.19 ± 7.43

0.032

4.06 ± 6.19

6.26 ± 5.61

0.366

4.88 ± 6.09

7.13 ± 4.99

0.325

5.91 ± 7.01

5.29 ± 3.51

0.781

 CD16+ %Mono

68.75 ± 13.39

75.44 ± 12.31

0.174

74.09 ± 13.74

69.72 ± 12.48

0.379

71.65 ± 13.52

76.50 ± 2.55

0.622

72.47 ± 13.28

71.19 ± 13.39

0.804

68.29 ± 14.51

73.39 ± 12.61

0.358

67.45 ± 13.04

80.59 ± 8.24

0.008

68.74 ± 13.19

76.58 ± 12.01

0.113

 NK %MNC

7.45 ± 16.28

3.58 ± 4.04

0.376

2.39 ± 1.63

9.10 ± 17.14

0.127

6.00 ± 12.81

1.60 ± 0.28

0.635

7.69 ± 16.47

3.28 ± 2.40

0.313

1.83 ± 0.92

7.15 ± 14.33

0.279

3.86 ± 4.56

8.78 ± 19.40

0.269

3.92 ± 4.75

8.06 ± 18.08

0.343

 CD56hi NK % MNC

5.69 ± 15.71

2.75 ± 3.90

0.502

1.56 ± 1.51

7.18 ± 16.30

0.221

4.54 ± 11.91

0.65 ± 0.21

0.653

5.95 ± 14.48

1.53 ± 1.33

0.325

1.34 ± 0.69

5.39 ± 13.45

0.407

2.33 ± 3.33

7.97 ± 19/17

0.379

2.28 ± 3.49

7.10 ± 17.47

0.274

 CD56lo NK % MNC

1.42 ± 2.55

0.97 ± .88

0.538

0.87 ± 0.86

1.56 ± 2.61

0.345

1.23 ± 1.98

0.90 ± 0.14

0.821

1.23 ± 2.34

1.15 ± 0.96

0.917

0.44 ± 0.41

1.50 ± 2.18

0.188

0.98 ± 0.85

1.63 ± 3.10

0.393

0.98 ± 0.89

1.52 ± 2.82

0.469

 CD56hi %NK

69.20 ± 19.96

63.24 ± 27.93

0.512

59.81 ± 26.37

73.30 ± 19.46

0.128

68.18 ± 23.71

41.25 ± 2.47

0.126

72.92 ± 22.72

55.53 ± 22.66

0.055

77.68 ± 16.96

62.00 ± 25.04

0.068

65.42 ± 24.16

68.03 ± 24.56

0.785

64.04 ± 24.68

69.56 ± 23.29

0.549

 MDSC % CD33hi

2.58 ± 3.27

2.22 ± 4.34

0.803

1.16 ± 1.92

3.74 ± 4.77

0.076

2.55 ± 3.86

0.50 ± 0.71

0.467

2.71 ± 4.15

1.92 ± 3.15

0.594

1.99 ± 2.98

2.57 ± 4.07

0.718

2.94 ± 4.48

1.39 ± 1.47

0.299

3.22 ± 4.66

1.26 ± 1.39

0.118

 DR- %14 + APC

12.53 ± 18.65

23.71 ± 16.82

0.102

19.69 ± 20.97

16.04 ± 15.69

0.602

19.25 ± 18.36

/

/

14.93 ± 15.86

22.83 ± 21.80

0.269

15.24 ± 18.16

18.95 ± 18.80

0.636

21.95 ± 19.33

10.27 ± 14.27

0.105

23.35 ± 19.78

10.23 ± 13.43

0.057

 DR- %16 + APC

1.64 ± 2.56

1.54 ± 3.35

0.931

2.06 ± 3.67

1.09 ± 1.83

0.382

1.59 ± 3.00

1.65 ± 2.19

0.978

1.56 ± 3.05

1.65 ± 2.83

0.931

2.81 ± 4.28

1.13 ± 2.17

0.169

2.37 ± 3.37

0.11 ± 0.16

0.009

2.42 ± 3.54

0.42 ± 0.95

0.038