Fig. 4
From: Heterogeneous components of lung adenocarcinomas confer distinct EGFR mutation and PD-L1 expression
a-e Kaplan–Meier curve for progression-free survival (PFS) and PD-L1 expression TPS in LACs with different histological patterns. a The median PFS survivals were compared in different LAC subtypes. LACs with predominant lepidic components had longer PFS time than other subtypes (P < 0.001). b Among LACs with acinar pattern, the median PFS of group PD-L1 TPS < 1% was significantly longer than that of PD-L1 > =50% (P = 0.031). c Among LACs with solid pattern, the median PFS of group PD-L1 TPS < 1% was slightly longer than that of PD-L1 TPS 1–49% group (P = 0.055). d The median PFS of groups PD-L1 TPS < 1, 1–49%, > = 50% in LACs with micropapillary components. PFS of group PD-L1 TPS < 1% was 24.6 months (95% CI 21.4–27.8), although not significant longer than those with higher TPS (P > 0.05). e The median PFS of groups PD-L1 TPS < 1, 1–49% and > =50% in LACs with papillary components. Longer PFS time was found in the group of PD-L1 TPS < 1%, however, no significant difference was found in these groups (P > 0.05)