The kinetic profile and clinical implication of SCC-Ag in squamous cervical cancer patients undergoing radical hysterectomy using the Simoa assay: a prospective observational study

Table 2 Correlation of clinical information with Simoa SCC-Ag values at different time points

	LVSI			Lymph node metastasis			FIGO stage			Stromal invasion
	Negative	Positive	p value^a	Negative	Positive	p value^a	IB	IIA	p value^a	<= 1/2	> 1/2	p value^a
	N = 38	N = 54	p value^a	N = 59	N = 33	p value^a	N = 38	N = 54	p value^a	N = 21	N = 71	p value^a
SCC-Ag (ng/ml), median[range]
Pre-surgery	1.98 [0.34;71.7]	4.22 [0.31;69.6]	0.074	1.76 [0.31;71.7]	8.72 [0.61;69.6]	< 0.001	1.40 [0.31;69.6]	3.88 [0.36;71.7]	0.003	1.10 [0.34;13.9]	3.49 [0.31;71.7]	< 0.001
Day 4 post-surgery	0.55 [0.17;1.72]	0.72 [0.21;5.10]	0.048	0.57 [0.17;5.10]	0.93 [0.33;5.06]	< 0.001	0.65 [0.17;5.06]	0.68 [0.32;5.10]	0.353	0.57 [0.17;1.19]	0.68 [0.21;5.10]	0.041
Week 2–4 post-surgery	0.47 [0.27;2.64]	0.69 [0.23;2.34]	0.013	0.52 [0.23;2.64]	0.78 [0.29;2.34]	0.003	0.57 [0.23;2.34]	0.63 [0.27;2.64]	0.371	0.69 [0.27;2.12]	0.61 [0.23;2.64]	0.858
Month 2–4 post-surgery	0.59 [0.25;2.77]	0.85 [0.30;24.2]	0.019	0.67 [0.25;2.77]	0.85 [0.30;24.2]	0.123	0.68 [0.25;24.2]	0.75 [0.35;2.77]	0.336	0.68 [0.30;1.45]	0.75 [0.25;24.2]	0.539
Month 5–7 post-surgery	0.54 [0.36;3.36]	0.77 [0.52;2.60]	0.117	0.66 [0.36;3.36]	0.72 [0.52;2.60]	0.273	0.71 [0.37;1.00]	0.71 [0.36;3.36]	0.477	0.58 [0.37;1.14]	0.71 [0.36;3.36]	0.415

Abbreviations: SCC-Ag Squamous cell carcinoma antigen, FIGO International Federation of Gynecology and Obstetrics, LVSI Lymph-vascular space invasion
^aKruskal-Wallis test

ISSN: 1471-2407