Fig. 3

Results of apoptotic cell percentages for tumor-bearing mice of both CT26 (a) and 4 T1 (b). Results obtained using MUSE® Cell Analyzer and apoptotic cell percentages are described as mean ± SEM in the three treatment groups including six mice each on Day 4 after treatment. Statistical significance was found using one-way ANOVA testing with p-value of 0.0077 for CT26 model, but no significance found for 4 T1 model. Bottom row presents correlation of ADC-results at Day 4 and apoptotic cell percentages on the same day for CT26 (c) and 4 T1 (d), respectively. ADC-values are extracted from MRI scans in ROI volume including central part of tumor, and here presented in original values at Day 4. Correlation analysis was made using Pearson correlation, resulting in values of r = 0.657 and p = 0.0031 for the CT26 tumors, and r = 0.508, p = 0.0319 for the 4 T1 tumors